Evidence map›Paper›PMID 27324049›Full record

ArticleJournal of molecular histology2016

Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

Sooraj Baijnath, Adeola Shobo, Linda A Bester, Sanil D Singh, Gert Kruger, Per I Arvidsson, Tricia Naicker, Thavendran Govender

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Sooraj BaijnathCatalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.
Adeola ShoboCatalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.
Linda A BesterBiomedical Resource Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Sanil D SinghBiomedical Resource Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Gert KrugerCatalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.
Per I ArvidssonCatalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.
Tricia NaickerCatalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.
Thavendran GovenderCatalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa. govenderthav@ukzn.ac.za.
University of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A study was undertaken to determine the neuroprotective potential of Linezolid (LIN) in an animal model. Female Sprague-Dawley rats were either given a single (100 mg/kg) dose or treated daily for 4 weeks. A validated LC-MS/MS method was used to measure LIN levels in plasma and brain, this was paired with mass spectrometry imaging to determine the tissue spatial distribution of the drug. The results showed that after a single dose there was poor penetration of the drug into the brain. With multiple doses there were high tissue levels, with the drug reaching steady state in subsequent weeks. LIN displayed a promising distribution pattern with localisation in the brainstem. Systemic circulation is fed into the brain by the carotid and vertebral arteries which enter through the brain stem, therefore high drug concentrations is this area may protect against infectious agents entering via this route.

Indexed as

AnimalsBrainChromatography, LiquidFemaleLinezolidMass SpectrometryNeuroprotective AgentsRatsTandem Mass SpectrometryTissue DistributionLinezolidNeuroprotective AgentsBrainLC–MS/MSLinezolidMolecular histologyMSINeuroprotection

Identifiers

PMID27324049
OpenAlexW2463527881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.