Evidence map›Paper›PMID 27323940›Full record

ReviewProgress in brain research2016

Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy.

X Jiang, M Lachance, E Rossignol

Open access · greenAbstract readReview
In one paragraph

Review in Progress in brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 102 citations in OpenAlex.

  1. Protective role of mirtazapine in adult female Mecp2Journal of neurodevelopmental disorders · 2020
    Trial
  2. Article
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  9. δ-Containing GABAJournal of neurophysiology · 2025
    Article
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  11. Review
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  15. Review
  16. Article
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  18. Review
  19. Human mutations inFrontiers in molecular neuroscience · 2024
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

X JiangUniversité de Montréal, Montréal, QC, Canada; CHU Ste-Justine Research Center, Montréal, QC, Canada.
M LachanceCHU Ste-Justine Research Center, Montréal, QC, Canada.
E RossignolUniversité de Montréal, Montréal, QC, Canada; CHU Ste-Justine Research Center, Montréal, QC, Canada. Electronic address: elsa.rossignol@umontreal.ca.
Centre Hospitalier Universitaire Sainte-Justine · CA

Funding

CIHR 119553-1
6 · The paper itself

Abstract

GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or function of PV INs has been associated with epilepsy in various animal models of epilepsy, as well as in some genetic forms of epilepsy in humans. In this review, we provide an overview of some of the experimental data linking PV INs dysfunction with epilepsy, focusing on disorders of the specification, migration, maturation, synaptic function, or connectivity of PV INs. Furthermore, we reflect on the potential therapeutic use of cell-type specific stimulation of PV INs within active networks and on the transplantation of PV INs precursors in the treatment of epilepsy and its comorbidities.

Indexed as

Action PotentialsAnimalsCerebral CortexEpilepsyHumansInterneuronsParvalbuminsParvalbuminsBasket cellsEpilepsyFast-spiking cellsGABAGenesInterneuronsParvalbumin

Identifiers

PMID27323940
PMCPMC5218834
OpenAlexW2495886275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.