Evidence map›Paper›PMID 27323329›Full record

ArticleNature cell biology2016

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

Robert S Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari, Anas Abdel Rahman, Judy Pawling, Wei Zhang, Ankit Sinha, Christopher M Rose and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 5 countries.

Robert S BanhDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Caterina Iorio *Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Richard Marcotte *Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Yang Xu *Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Dan CojocariDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Anas Abdel RahmanLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Judy PawlingLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Wei ZhangDonnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.
Ankit SinhaDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Christopher M RoseDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Marta IsasaDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Shuang ZhangLaura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York University, New York, NY 10016, USA.
Ronald WuDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Carl VirtanenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Toshiaki HitomiDepartment of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toshiyuki HabuDepartment of Radiation System Biology, Institute of Radiation Biology Center, Kyoto University, Kyoto, Japan.
Sachdev S SidhuDonnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.
Akio KoizumiDepartment of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sarah E WilkinsChemistry Research Laboratory, Oxford University, 12 Mansfield Road, Oxford OX1 3TA, UK.
Thomas KislingerDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Christopher J SchofieldChemistry Research Laboratory, Oxford University, 12 Mansfield Road, Oxford OX1 3TA, UK.
James W DennisLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Bradly G WoutersDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Benjamin G NeelPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
University Health Network · CAHarvard University · USKyoto University · JPMount Sinai Hospital · CAOxford Research Group · GBUniversity of Toronto · CANYU Langone Health · US

Funding

SIGNAL TRANSDUCTION BY NON-TRANSMEMBRANE PTPSR01CA049152 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEEL, BENJAMIN G. · 1989 to 2020
$4.4M
Signal Transduction by Non-transmembrane PTPsR37CA049152 · NCI · UNIVERSITY HEALTH NETWORK · PI NEEL, BENJAMIN G. · 2004 to 2013
$4.0M
Biotechnology and Biological Sciences Research Council BB/D011523/1Cancer Research UKCIHR 120593CIHR 133615CIHR 136956CIHR 62975NCI NIH HHS R01 CA049152NCI NIH HHS R37 CA049152Wellcome Trust
6 · The paper itself

Abstract

Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption. Hypoxia-inducible factor (HIF) controls mitochondrial oxygen consumption, but how/if tumours regulate non-mitochondrial oxygen consumption (NMOC) is unknown. Protein-tyrosine phosphatase-1B (PTP1B) is required for Her2/Neu-driven breast cancer (BC) in mice, although the underlying mechanism and human relevance remain unclear. We found that PTP1B-deficient HER2(+) xenografts have increased hypoxia, necrosis and impaired growth. In vitro, PTP1B deficiency sensitizes HER2(+) BC lines to hypoxia by increasing NMOC by α-KG-dependent dioxygenases (α-KGDDs). The moyamoya disease gene product RNF213, an E3 ligase, is negatively regulated by PTP1B in HER2(+) BC cells. RNF213 knockdown reverses the effects of PTP1B deficiency on α-KGDDs, NMOC and hypoxia-induced death of HER2(+) BC cells, and partially restores tumorigenicity. We conclude that PTP1B acts via RNF213 to suppress α-KGDD activity and NMOC. This PTP1B/RNF213/α-KGDD pathway is critical for survival of HER2(+) BC, and possibly other malignancies, in the hypoxic tumour microenvironment.

Indexed as

Adenosine TriphosphatasesAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsBreast NeoplasmsCell HypoxiaFemaleGenes, erbB-2HumansMiceMitochondriaOxygen ConsumptionProtein Tyrosine Phosphatase, Non-Receptor Type 1Ubiquitin-Protein LigasesAdenosine TriphosphatasesAlpha-Ketoglutarate-Dependent Dioxygenase FTOProtein Tyrosine Phosphatase, Non-Receptor Type 1PTPN1 protein, humanPtpn1 protein, mouseRNF213 protein, humanRNF213 protein, mouseUbiquitin-Protein Ligases

Identifiers

PMID27323329
PMCPMC4936519
OpenAlexW2470758117

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.