Evidence map›Paper›PMID 27322875›Full record

ArticleHuman vaccines & immunotherapeutics2016

A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.

Kristin L Griffiths, Daniel O Villarreal, David B Weiner, Shabaana A Khader

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kristin L Griffithsa Department of Molecular Microbiology , Washington University in St. Louis , St. Louis , MO , USA.
Daniel O Villarrealb Department of Pathology and Laboratory Medicine , University of Pennsylvania School of Medicine , Philadelphia , PA , USA.
David B Weinerb Department of Pathology and Laboratory Medicine , University of Pennsylvania School of Medicine , Philadelphia , PA , USA.
Shabaana A Khadera Department of Molecular Microbiology , Washington University in St. Louis , St. Louis , MO , USA.
University of Pennsylvania · USWashington University in St. Louis · US

Funding

Synthetic DNA & Novel Env Vaccine for HIVU19AI109646 · NIAID · WISTAR INSTITUTE · PI SARDESAI, NIRANJAN Y · 2015 to 2019
$16.7M
ROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9M
Development of a Universal Influenza Seasonal VaccineR01AI092843 · NIAID · WISTAR INSTITUTE · PI WEINER, DAVID B. · 2010 to 2014
$3.0M
NHLBI NIH HHS R01 HL105427NIAID NIH HHS R01 AI092843NIAID NIH HHS U19 AI078675NIAID NIH HHS U19 AI109646
6 · The paper itself

Abstract

Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.

Indexed as

AnimalsDisease Models, AnimalHumansMice, Inbred C57BLMycobacterium tuberculosisTuberculosisTuberculosis VaccinesTuberculosis VaccinesDNA vaccineTuberculosisvaccine

Identifiers

PMID27322875
PMCPMC5085007
OpenAlexW2466036181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.