ArticlePLoS computational biology2016
Filopodial-Tension Model of Convergent-Extension of Tissues.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Model recapitulates regenerative limb blastema formation through local softening of the wounded epithelium.bioRxiv : the preprint server for biology · 2026Article
- Start small: A model for tissue-wide planar cell polarity without morphogens.PLoS computational biology · 2026Article
- Inferring active and passive mechanical drivers of epithelial convergent extension.bioRxiv : the preprint server for biology · 2025Article
- Article
- Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of Xenopus mesendoderm.Biology open · 2024Article
- The shapes of elongating gastruloids are consistent with convergent extension driven by a combination of active cell crawling and differential adhesion.PLoS computational biology · 2024Article
- Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Review
- Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction.Cell reports · 2022Article
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- Article
- A mechanical model of early somite segmentation.iScience · 2021Article
- Self-sustained planar intercalations due to mechanosignaling feedbacks lead to robust axis extension during morphogenesis.Scientific reports · 2020Article
- A direct role for SNX9 in the biogenesis of filopodia.The Journal of cell biology · 2020Article
- Model to Link Cell Shape and Polarity with Organogenesis.iScience · 2020Article
- Convergent extension in the amphibian, Xenopus laevis.Current topics in developmental biology · 2020Review
- Article
- Complex structures from patterned cell sheets.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
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Authors and funding
3 authors.
Funding
Abstract
In convergent-extension (CE), a planar-polarized epithelial tissue elongates (extends) in-plane in one direction while shortening (converging) in the perpendicular in-plane direction, with the cells both elongating and intercalating along the converging axis. CE occurs during the development of most multicellular organisms. Current CE models assume cell or tissue asymmetry, but neglect the preferential filopodial activity along the convergent axis observed in many tissues. We propose a cell-based CE model based on asymmetric filopodial tension forces between cells and investigate how cell-level filopodial interactions drive tissue-level CE. The final tissue geometry depends on the balance between external rounding forces and cell-intercalation traction. Filopodial-tension CE is robust to relatively high levels of planar cell polarity misalignment and to the presence of non-active cells. Addition of a simple mechanical feedback between cells fully rescues and even improves CE of tissues with high levels of polarity misalignments. Our model extends easily to three dimensions, with either one converging and two extending axes, or two converging and one extending axes, producing distinct tissue morphologies, as observed in vivo.
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Registered trials
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