ArticleInternational journal of molecular sciences2016
Antibacterial Activity of Juglone against Staphylococcus aureus: From Apparent to Proteomic.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Performance of Juglone as a Natural Extract for Inhibiting SRB-Induced Corrosion of Q235 Steel in Seawater.Microorganisms · 2026Article
- Antimicrobial activity and possible mechanisms of juglone against Escherichia coli, Staphylococcus aureus, and Salmonella pullorum.BMC microbiology · 2025Article
- Glucose-Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Chemical composition, antioxidant, antimicrobial, and anticancer activities of Mahonia napaulensis DC. bark from Nepal.BMC complementary medicine and therapies · 2025Article
- Article
- Antibacterial activities of anthraquinones: structure-activity relationships and action mechanisms.RSC medicinal chemistry · 2023Review
- Novel 2-Amino-1,4-Naphthoquinone Derivatives Induce A549 Cell Death through Autophagy.Molecules (Basel, Switzerland) · 2023Article
- Antibacterial Activity of Juglone Revealed in a Wound Model ofInternational journal of molecular sciences · 2023Article
- Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies.Frontiers of environmental science & engineering · 2023Article
- Antibacterial and Antibiofilm Activity of Juglone Derivatives againstBioMed research international · 2022Article
- Use of Acetic Acid to Partially Replace Lactic Acid for Decontamination againstFoods (Basel, Switzerland) · 2021Article
- Multifunctional Therapeutic Potential of Phytocomplexes and Natural Extracts for Antimicrobial Properties.Antibiotics (Basel, Switzerland) · 2021Review
- Article
- Synthesis, Structure Elucidation, Antibacterial Activities, and Synergistic Effects of Novel Juglone and Naphthazarin Derivatives Against Clinical Methicillin-ResistantFrontiers in chemistry · 2021Article
- Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi.Journal of bioenergetics and biomembranes · 2020Article
- Antimicrobial Susceptibility and Antibacterial Mechanism of Limonene againstMolecules (Basel, Switzerland) · 2019Article
- Quantitative Proteomics of Potato Leaves Infected withInternational journal of molecular sciences · 2019Article
- Characterization of Microcapsule Containing Walnut (International journal of preventive medicine · 2018Article
- Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis.Oncology reports · 2017Article
- iTRAQ-Based Proteomic Analysis of Sublethally InjuredFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proportion of foodborne disease caused by pathogenic microorganisms is rising worldwide, with staphylococcal food poisoning being one of the main causes of this increase. Juglone is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities. However, the specific mechanism underlying its antibacterial activity against Staphylococcus aureus remains unclear. To elucidate the mechanism underlying its antibacterial activity, isobaric tags for relative and absolute quantitation methods of quantitative proteomics were applied for analysis of the 53 proteins that were differentially expressed after treatment with juglone. Combined with verification experiments, such as detection of changes in DNA and RNA content and quantification of oxidative damage, our results suggested that juglone effectively increased the protein expression of oxidoreductase and created a peroxidative environment within the cell, significantly reducing cell wall formation and increasing membrane permeability. We hypothesize that juglone binds to DNA and reduces DNA transcription and replication directly. This is the first study to adopt a proteomic approach to investigate the antibacterial mechanism of juglone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.