ArticleInternational journal of molecular sciences2016
Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021Pooled it
- Linezolid for drug-resistant pulmonary tuberculosis.The Cochrane database of systematic reviews · 2019Pooled it
- 3-month daily rifampicin and isoniazid compared to 6- or 9-month isoniazid for treating latent tuberculosis infection in children and adolescents less than 15 years of age: an updated systematic review.The European respiratory journal · 2018Pooled it
- Fixed Dose Combinations as an Advantage for the Treatment of Pediatric Tuberculosis: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Pediatric drug-sensitive tuberculosis treatment regimen profiles and treatment outcomes in mainland China, 2017-2022: a multi-center study.BMC infectious diseases · 2025Observational
- Multi-view deep learning framework for the detection of chest X-rays compatible with pediatric pulmonary tuberculosis.Nature communications · 2025Article
- Pediatric tuberculosis in Mexico: A retrospective analysis of 100 patients.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Epidemiology of tuberculosis among children in Beijing, China, 2012-2021.Epidemiology and infection · 2024Article
- [Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment].Cadernos de saude publica · 2024Article
- Epidemiology of extrapulmonary tuberculosis among pediatric inpatients in mainland China: a descriptive, multicenter study.Emerging microbes & infections · 2022Article
- Chest CT Scan for the Diagnosis of Pediatric Pulmonary TB: Radiological Findings and Its Diagnostic Significance.Frontiers in pediatrics · 2021Article
- Characteristics of paediatric patients with tuberculosis and associated determinants of treatment success in Malaysia using the MyTB version 2.1 database over five years.BMC public health · 2020Article
- Peritoneal tuberculosis mimicking carcinomatous ascites in a child living in a low prevalence country: a case report.Italian journal of pediatrics · 2020Article
- Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?Journal of immunology research · 2020Article
- Case Report: Multifocal Tubercular Osteomyelitis of the Spine and Bilateral Dactylitis.The American journal of tropical medicine and hygiene · 2019Article
- Evaluation of Clinical and Laboratory Characteristics of Children with Pulmonary and Extrapulmonary Tuberculosis.Medicina (Kaunas, Lithuania) · 2019Article
- Drug-Resistant Tuberculosis among Children, China, 2006-2015.Emerging infectious diseases · 2017Article
- Pediatric Tuberculosis in Northern Sardinia.Mediterranean journal of hematology and infectious diseases · 2017Article
- Infectious Diseases: Pathophysiology, Diagnostics and Prevention.International journal of molecular sciences · 2016Article
- Pediatric Tuberculosis Disease during Years of High Refugee Arrivals: A 6-Year National Prospective Surveillance Study.Respiration; international review of thoracic diseasesArticle
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Authors and funding
49 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, and public health centers in Italy using a standardized form, covering the period of time between 1 January 2010 and 31 December 2012. Children with active TB, latent TB, and those recently exposed to TB or recently adopted/immigrated from a high TB incidence country were enrolled. Overall, 4234 children were included; 554 (13.1%) children had active TB, 594 (14.0%) latent TB and 3086 (72.9%) were uninfected. Among children with active TB, 481 (86.8%) patients had pulmonary TB. The treatment of active TB cases was known for 96.4% (n = 534) of the cases. Overall, 210 (39.3%) out of these 534 children were treated with three and 216 (40.4%) with four first-line drugs. Second-line drugs where used in 87 (16.3%) children with active TB. Drug-resistant strains of Mycobacterium tuberculosis were reported in 39 (7%) children. Improving the surveillance of childhood TB is important for public health care workers and pediatricians. A non-negligible proportion of children had drug-resistant TB and was treated with second-line drugs, most of which are off-label in the pediatric age. Future efforts should concentrate on improving active surveillance, diagnostic tools, and the availability of antitubercular pediatric formulations, also in low-endemic countries.
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