ArticlePloS one2016
Nitrogen Gas Plasma Generated by a Static Induction Thyristor as a Pulsed Power Supply Inactivates Adenovirus.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Impact of needle-point bipolar ionization system in the reduction of bioaerosols in collective transport.The Science of the total environment · 2023Article
- Recent Advances in Prion Inactivation by Plasma Sterilizer.International journal of molecular sciences · 2022Review
- Removal of chemical and microbial water pollutants by cold plasma combined with Ag/TiOScientific reports · 2022Article
- Plasma Biology 2.0.International journal of molecular sciences · 2022Article
- Cold atmospheric plasma: A non-negligible strategy for viral RNA inactivation to prevent SARS-CoV-2 environmental transmission.AIP advances · 2021Article
- Inactivation of Pepper Mild Mottle Virus in Water by Cold Atmospheric Plasma.Frontiers in microbiology · 2021Article
- Cold Plasma, a New Hope in the Field of Virus Inactivation.Trends in biotechnology · 2020Review
- Foodborne Viruses and Innovative Non-Thermal Food-Processing Technologies.Foods (Basel, Switzerland) · 2020Review
- Effect of Nitrogen Gas Plasma Generated by a Fast-Pulsed Power Supply Using a Static Induction Thyristor on Scrapie Prion.Pathogens (Basel, Switzerland) · 2020Article
- Disinfection and Sterilization Using Plasma Technology: Fundamentals and Future Perspectives for Biological Applications.International journal of molecular sciences · 2019Review
- Key role of singlet oxygen and peroxynitrite in viral RNA damage during virucidal effect of plasma torch on feline calicivirus.Scientific reports · 2018Article
- Cold argon-oxygen plasma species oxidize and disintegrate capsid protein of feline calicivirus.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenovirus is one of the most important causative agents of iatrogenic infections derived from contaminated medical devices or finger contact. In this study, we investigated whether nitrogen gas plasma, generated by applying a short high-voltage pulse to nitrogen using a static induction thyristor power supply (1.5 kilo pulse per second), exhibited a virucidal effect against adenoviruses. Viral titer was reduced by one log within 0.94 min. Results from detection of viral capsid proteins, hexon and penton, by Western blotting and immunochromatography were unaffected by the plasma treatment. In contrast, analysis using the polymerase chain reaction suggested that plasma treatment damages the viral genomic DNA. Reactive chemical products (hydrogen peroxide, nitrate, and nitrite), ultraviolet light (UV-A) and slight temperature elevations were observed during the operation of the gas plasma device. Viral titer versus intensity of each potential virucidal factor were used to identify the primary mechanism of disinfection of adenovirus. Although exposure to equivalent levels of UV-A or heat treatment did not inactivate adenovirus, treatment with a relatively low concentration of hydrogen peroxide efficiently inactivated the virus. Our results suggest the nitrogen gas plasma generates reactive chemical products that inactivate adenovirus by damaging the viral genomic DNA.
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