Evidence map›Paper›PMID 27321608›Full record

Trial reportJournal of the American Geriatrics Society2016

Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study.

Feng Lin, Kathi L Heffner, Ping Ren, Madalina E Tivarus, Judith Brasch, Ding-Geng Chen, Mark Mapstone, Anton P Porsteinsson, Duje Tadin

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03577717 (Efficacy of Computerized Cognitive Training in the Elderly With Mild Cognitive Impairment), which is not on this map. Cited by 67 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 12 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03577717 naterminatednot on this mapstarted 2018, after this paper: background citation

Efficacy of Computerized Cognitive Training in the Elderly With Mild Cognitive Impairment: Clinical Outcomes and Magnetoencephalographic Imaging

TypeinterventionalSponsorTaipei Hospital, TaiwanRan2018 to 2019Enrolled7ConditionsMild Cognitive ImpairmentArmscomputerized cognitive training, occupational therapy
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 12 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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  10. A Systematic Review for Functional Neuroimaging Studies of Cognitive Reserve Across the Cognitive Aging Spectrum.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018
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  18. Attitudes Toward Computers Moderate the Effect of Computerized Cognitive Trainings in Oldest-Old Senior Living Center Residents.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
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  20. The Effects of Useful Field of View Training on Brain Activity and Connectivity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Feng LinSchool of Nursing, University of Rochester, Rochester, New York.
Kathi L HeffnerDepartment of Psychiatry, University of Rochester, Rochester, New York.
Ping RenSchool of Nursing, University of Rochester, Rochester, New York.
Madalina E TivarusDepartment of Imaging Sciences, University of Rochester, Rochester, New York.
Judith BraschSchool of Nursing, University of Rochester, Rochester, New York.
Ding-Geng ChenSchool of Nursing, University of Rochester, Rochester, New York.
Mark MapstoneDepartment of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, New York.
Anton P PorsteinssonDepartment of Psychiatry, University of Rochester, Rochester, New York.
Duje TadinDepartment of Ophthalmology, University of Rochester, Rochester, New York.
University of Rochester · US

Funding

Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive ImpairmentR01NR015452 · NINR · UNIVERSITY OF ROCHESTER · PI HEFFNER, KATHI L, LIN, FENG VANKEE · 2015 to 2024
$4.4M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
NCATS NIH HHS KL2 TR000095NINR NIH HHS R01 NR015452
6 · The paper itself

Abstract

objectivesTo examine the cognitive and neural effects of vision-based speed-of-processing (VSOP) training in older adults with amnestic mild cognitive impairment (aMCI) and contrast those effects with an active control (mental leisure activities (MLA)).

designRandomized single-blind controlled pilot trial.

settingAcademic medical center.

participantsIndividuals with aMCI (N = 21).

interventionSix-week computerized VSOP training. MEASUREMENTS: Multiple cognitive processing measures, instrumental activities of daily living (IADLs), and two resting state neural networks regulating cognitive processing: central executive network (CEN) and default mode network (DMN).

resultsVSOP training led to significantly greater improvements in trained (processing speed and attention: F1,19  = 6.61, partial η(2)  = 0.26, P = .02) and untrained (working memory: F1,19  = 7.33, partial η(2)  = 0.28, P = .01; IADLs: F1,19  = 5.16, partial η(2)  = 0.21, P = .03) cognitive domains than MLA and protective maintenance in DMN (F1, 9  = 14.63, partial η(2)  = 0.62, P = .004). VSOP training, but not MLA, resulted in a significant improvement in CEN connectivity (Z = -2.37, P = .02).

conclusionTarget and transfer effects of VSOP training were identified, and links between VSOP training and two neural networks associated with aMCI were found. These findings highlight the potential of VSOP training to slow cognitive decline in individuals with aMCI. Further delineation of mechanisms underlying VSOP-induced plasticity is necessary to understand in which populations and under what conditions such training may be most effective.

Indexed as

Computer-Assisted InstructionPhotic StimulationActivities of Daily LivingAgedAmnesiaAttentionCognitive DysfunctionComprehensionFemaleGeriatric AssessmentHumansMaleNeuropsychological TestsPilot ProjectsSingle-Blind MethodTreatment Outcomecentral executive networkdefault mode networkmild cognitive impairmentspeed of processing

Identifiers

PMID27321608
PMCPMC4916855
OpenAlexW2430648854

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.