Trial reportJournal of the American Geriatrics Society2016
Inflammatory Biomarkers and Cognitive Decline: The Ginkgo Evaluation of Memory Study.
Trial report in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictors of cognitive decline in older individuals without dementia: An updated meta-analysis.Annals of clinical and translational neurology · 2023Pooled it
- Association of inflammation and cognition in the elderly: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Decreased resistin plasmatic concentrations in patients with Alzheimer's disease: A case-control study.Heliyon · 2022Article
- Relationships between Inflammation and Age-Related Neurocognitive Changes.International journal of molecular sciences · 2022Review
- A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals.Journal of clinical medicine · 2021Article
- Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- A novel biomarker of cardiometabolic pathology in schizophrenia?Journal of psychiatric research · 2019Article
- Few serum proteins mediate APOE's association with dementia.PloS one · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo examine the association between inflammatory biomarkers and global cognitive function.
designCase-cohort.
settingGinkgo Evaluation of Memory Study.
participantsIndividuals aged 75 and older free of neurological or neurodegenerative conditions recruited from 2000 to 2002 (N = 1,315). MEASUREMENTS: Outcome was cognitive function assessed using the modified Mini-Mental State Examination (3MSE) every 6 months for up to 7 years. Exposures were 10 biomarkers measured at baseline: interleukin-2, -6, and -10 (general systemic inflammation); pentraxin 3 (PTX3) and serum amyloid P (SAP) (vascular inflammation); plasminogen activator inhibitor-1, adiponectin, and resistin (metabolic function); receptor for advanced glycation endproduct (oxidative stress); and endothelin-1 (endothelial function). Associations between biomarkers and 3MSE scores (stratified according to mild cognitive impairment (MCI) at baseline) were analyzed using Cox regression (outcome: 3MSE decline of ≥5 points) and mixed-model regression. Bonferroni correction was used to determine significance threshold (P < .0025).
resultsIn individuals with baseline MCI, PTX3 was associated with a 20% greater hazard of cognitive decline (95% confidence interval = 1.07-1.35), although this association was no longer statistically significant after adjustment for apolipoprotein (APO)E ε4 allele. Adiponectin was associated with faster rate of 3MSE decline in individuals without baseline MCI in mixed-model regression, but the association was similarly attenuated after adjustment for APOE-ε4.
conclusionThis study did not find strong evidence of the utility of the biomarkers evaluated for identifying individuals at risk of cognitive decline. Future studies investigating the association between PTX3, SAP, and adiponectin and 3MSE scores may be useful.
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