Trial reportFood additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment2016
Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin.
Trial report in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Risk Factors for Hepatocellular Carcinoma in Latino Populations in Texas: A Scoping Review.International journal of molecular sciences · 2026Article
- Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.Annals of translational medicine · 2026Review
- Ubiquitous Environmental Exposures and Risk of Hepatocellular Carcinoma: A Narrative Review.Digestive diseases and sciences · 2026Review
- Caffeine, riboflavin and curcumin amended clays for PFAS binding.Computers & chemical engineering · 2025Article
- β-Lactoglobulin Enhances Clay and Activated Carbon Binding and Protection Properties for Cadmium and Lead.Industrial & engineering chemistry research · 2024Article
- Article
- Increase in aflatoxin exposure in two populations residing in East and West Texas, United States.International journal of hygiene and environmental health · 2021Article
- Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays.Computers & chemical engineering · 2020Article
- Evaluation of acute and chronic exposure to aflatoxin BEnvironmental science and pollution research international · 2020Article
- Montmorillonites Can Tightly Bind Glyphosate and Paraquat Reducing Toxin Exposures and Toxicity.ACS omega · 2019Article
- NovaSil clay for the protection of humans and animals from aflatoxins and other contaminants.Clays and clay minerals · 2019Article
- Development of enterosorbents that can be added to food and water to reduce toxin exposures during disasters.Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes · 2019Article
- Development of High Capacity Enterosorbents for Aflatoxin B1 and Other Hazardous Chemicals.Chemical research in toxicology · 2017Article
- Lifestyle and Clinical Correlates of Hepatocellular Carcinoma in South Texas: A Matched Case-control Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- Evaluation of the efficacy, acceptability and palatability of calcium montmorillonite clay used to reduce aflatoxin B1 dietary exposure in a crossover study in Kenya.Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
South Texas currently has the highest incidence of hepatocellular carcinoma (HCC) in the United States, a disease that disproportionately affects Latino populations in the region. Aflatoxin B1 (AFB1) is a potent liver carcinogen that has been shown to be present in a variety of foods in the United States, including corn and corn products. Importantly, it is a dietary risk factor contributing to a higher incidence of HCC in populations frequently consuming AFB1-contaminated diets. In a randomised double-blind placebo controlled trial, we evaluated the effects of a 3-month administration of ACCS100 (refined calcium montmorillonite clay) on serum AFB1-lysine adduct (AFB-Lys) level and serum biochemistry in 234 healthy men and women residing in Bexar and Medina counties, Texas. Participants recruited from 2012 to 2014 received either a placebo, 1.5 g or 3 g ACCS100 each day for 3 months, and no treatment during the fourth month. Adverse event rates were similar across treatment groups and no significant differences were observed for serum biochemistry and haematology parameters. Differences in levels of AFB-Lys at 1, 3 and 4 months were compared between placebo and active treatment groups. Although serum AFB-Lys levels were decreased by month 3 for both treatment groups, the low dose was the only treatment that was significant (p = 0.0005). In conclusion, the observed effect in the low-dose treatment group suggests that the use of ACCS100 may be a viable strategy to reduce dietary AFB1 bioavailability during aflatoxin outbreaks and potentially in populations chronically exposed to this carcinogen.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.