ArticleNeurobiology of learning and memory2016
The role of nuclear PKMζ in memory maintenance.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages.Experimental neurobiology · 2022Review
- Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage.The European journal of neuroscience · 2021Article
- Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation.Scientific reports · 2020Article
- Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation.Frontiers in computational neuroscience · 2020Article
- Article
- Experiments with Snails Add to Our Knowledge about the Role of aPKC Subfamily Kinases in Learning.International journal of molecular sciences · 2019Article
- In memoriam: John Lisman - commentaries on CaMKII as a memory molecule.Molecular brain · 2018Article
- The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition.Frontiers in systems neuroscience · 2018Article
- Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta).Molecular brain · 2017Review
- The genetics of PKMζ and memory maintenance.Science signaling · 2017Review
- Kinases of eIF2a Switch Translation of mRNA Subset during Neuronal Plasticity.International journal of molecular sciences · 2017Review
- Persistent increased PKMζ in long-term and remote spatial memory.Neurobiology of learning and memory · 2017Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.