ArticleScientific reports2016
Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development.Developmental biology · 2025Article
- Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development.bioRxiv : the preprint server for biology · 2025Article
- The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells.Nature cell biology · 2025Article
- Nuclear instance segmentation and tracking for preimplantation mouse embryos.Development (Cambridge, England) · 2024Article
- Depolarization diagrams for circularly polarized light scattering for biological particle monitoring.Journal of biomedical optics · 2024Article
- The salt-and-pepper pattern in mouse blastocysts is compatible with signaling beyond the nearest neighbors.iScience · 2023Article
- The large cytoplasmic volume of oocyte.The Journal of reproduction and development · 2023Review
- Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023Review
- Tetraploid embryo aggregation produces high-quality blastocysts with an increased trophectoderm in pigs.Frontiers in cell and developmental biology · 2023Article
- Cell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The uniformity and stability of cellular mass density in mammalian cell culture.Frontiers in cell and developmental biology · 2022Article
- Article
- Larger cells have relatively smaller nuclei across the Tree of Life.Evolution letters · 2021Article
- IVEN: A quantitative tool to describe 3D cell position and neighbourhood reveals architectural changes in FGF4-treated preimplantation embryos.PLoS biology · 2021Article
- Article
- Integrating cellular dimensions with cell differentiation during early development.Current opinion in cell biology · 2020Review
- DNA content contributes to nuclear size control inMolecular biology of the cell · 2020Article
- 3D convolutional neural networks-based segmentation to acquire quantitative criteria of the nucleus during mouse embryogenesis.NPJ systems biology and applications · 2020Article
- Organelle size scaling over embryonic development.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Assessing heterogeneity among single embryos and single blastomeres using open microfluidic design.Science advances · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Maintaining appropriate nucleus size is important for cell health, but the mechanisms by which this is achieved are poorly understood. Controlling nucleus size is a particular challenge in early development, where the nucleus must downscale in size with progressive reductive cell divisions. Here we use live and fixed imaging, micromanipulation approaches, and small molecule analyses during preimplantation mouse development to probe the mechanisms by which nucleus size is determined. We find a close correlation between cell and nuclear size at any given developmental stage, and show that experimental cytoplasmic reduction can alter nuclear size, together indicating that cell size helps dictate nuclear proportions. Additionally, however, by creating embryos with over-sized blastomeres we present evidence of a developmental program that drives nuclear downscaling independently of cell size. We show that this developmental program does not correspond with nuclear import rates, but provide evidence that PKC activity may contribute to this mechanism. We propose a model in which nuclear size regulation during early development is a multi-mode process wherein nucleus size is set by cytoplasmic factors, and fine-tuned on a cell-by-cell basis according to cell size.
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Registered trials
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