ArticleDepression and anxiety2016
ANTIDEPRESSANT ADHERENCE ACROSS DIVERSE POPULATIONS AND HEALTHCARE SETTINGS.
Article in Depression and anxiety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06799078 (Racial Disparities in Antidepressant Initiation, Titration, and Adherence After Receiving a Psychiatric Consultation), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Racial Disparities in Antidepressant Initiation, Titration, and Adherence After Receiving a Psychiatric Consultation
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Therapeutic effects of psilocybin in major depressive disorder: a systematic review and meta-analysis exploring dose effects.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Effectiveness of reminiscence therapy on multiple health outcomes for older adults: an umbrella review.BMC geriatrics · 2025Pooled it
- Medication non-adherence in depression: a systematic review and metanalysis.Trends in psychiatry and psychotherapy · 2025Pooled it
- Improving depression management with support from close others: A thematic analysis of individuals with depression and their partners in care.Chronic illness · 2024Trial
- Adherence to Depression Treatment in Primary Care: A Randomized Clinical Trial.JAMA psychiatry · 2017Trial
- Article
- Definition of treatment-resistant late-life depression: Conclusions from a European Task Force Delphi process.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Impact of pharmaceutical care interventions on antidepressants adherence and clinical outcomes in depressed patients: A systematic review.Exploratory research in clinical and social pharmacy · 2025Review
- Psychiatric Medication Adherence in the United States Before and During the COVID-19 Pandemic.Pharmacoepidemiology and drug safety · 2025Article
- Gut-Brain Axis in Mood Disorders: A Narrative Review of Neurobiological Insights and Probiotic Interventions.Biomedicines · 2025Review
- Comparing In-Person, Telephonic, and Video-Based Treatment of Depression in Adult Primary Care During the COVID-19 Pandemic.The Permanente journal · 2025Article
- KETO-MOOD: Ketogenic Diet for Microbiome Optimization and Overcoming Depression - A Protocol for a Randomized Controlled Trial.Neuroimmunomodulation · 2025Article
- Review
- Dietary Habits and Depression in Community-Dwelling Chinese Older Adults: Cross-Sectional Analysis of the Moderating Role of Physical Exercise.Nutrients · 2024Article
- A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity.Frontiers in pharmacology · 2024Article
- Liraglutide 3.0 mg and mental health: can psychiatric symptoms be associated to adherence to therapy? Insights from a clinical audit.Eating and weight disorders : EWD · 2023Article
- Prevalence and prediction of dropout during depression treatment in routine outpatient care: an observational study.European archives of psychiatry and clinical neuroscience · 2023Observational
- Income-related disparities in Medicare advantage behavioral health care quality.Health services research · 2023Article
- Psychosocial interventions to improve adherence in depressed and anxious older adults prescribed antidepressant pharmacotherapy: a scoping review.Therapeutic advances in psychopharmacology · 2023Article
- Identifying temporal patterns of adherence to antidepressants, bisphosphonates and statins, and associated patient factors.SSM - population health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundEarly adherence is key to successful depression treatment, but nearly 60% of patients discontinue antidepressants within 3 months. Our study aimed to determine factors associated with poor early adherence to antidepressants in a large diverse sample of patients.
methodsSix Mental Health Research Network healthcare systems contributed data for adults with depression and a new antidepressant start, defined by a washout period of at least 270 days, between January 1, 2010 and December 31, 2012. Pharmacy fill and self-reported race/ethnicity data were obtained from the electronic medical record. Patients had early adherence if they had a second antidepressant fill within 180 days of the first. We used logistic regression to investigate the relationship between early adherence and patient characteristics.
resultsA total of 177,469 adult patients had 184,967 new episodes of depression with a filled antidepressant prescription. Patients refilled their antidepressants within 180 days in 71% of episodes. Race/ethnicity was a strong predictor of early adherence, with patients from racial/ethnic minorities other than Native Americans/Alaskan Natives less likely (adjusted odd ratios 0.50-0.59) to refill their antidepressants than non-Hispanic whites. Age, neighborhood education, comorbidity burden, provider type and engagement in psychotherapy were also associated with adherence. Other apparent predictors of early adherence, including neighborhood income, gender, and prior mental health hospitalizations, were no longer significant in the fully adjusted model.
conclusionsRace/ethnicity was a robust predictor of early antidepressant adherence, with minority groups other than Native Americans/Alaskan Natives less likely to be adherent. Further research is needed to determine whether early nonadherence in specific minority populations is intentional, due to side effects or patient preference, or unintentional and appropriate for targeted interventions to improve adherence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.