ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Radiomics as a tool for predicting biochemical recurrence after total prostatectomy: a systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- Prevalence and clinical application ofAsian journal of andrologyPooled it
- Deep Sequencing Reveals Novel Mutations inInternational journal of molecular sciences · 2025Article
- Molecular characterization of prostate cancer in Middle Eastern population highlights differences with Western populations with prognostic implication.Journal of cancer research and clinical oncology · 2020Article
- TMPRSS2: Potential Biomarker for COVID-19 Outcomes.Journal of clinical pharmacology · 2020Article
- ERG Tumor Type is Less Frequent in High Grade and High Stage Prostate Cancers of Chinese Men.Journal of Cancer · 2019Article
- Urinary markers aiding in the detection and risk stratification of prostate cancer.Translational andrology and urology · 2018Review
- Ethnicity and ERG frequency in prostate cancer.Nature reviews. Urology · 2018Review
- Prostate cancer in Jordanian-Arab population: ERG status and relationship with clinicopathologic characteristics.Virchows Archiv : an international journal of pathology · 2017Article
- Expression of ERG Protein and TMRPSS2-ERG Fusion in Prostatic Carcinoma in Egyptian Patients.Open access Macedonian journal of medical sciences · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer is the commonest male malignancy in the Western world, but its morbidity is much lower in China. The principal aim of this study was to evaluate the frequency of TMPRSS2:ERG fusion in Chinese prostate cancer patients using immunohistochemistry and reverse transcription polymerase chain (RT-PCR). In addition, we compared the ERG protein expression with TMPRSS2:ERG fusion gene. The relationship between ERG expression and clinicopathologic features was also examined. Samples from patients who underwent radical prostatectomies in Changhai Hospital (Shanghai, China) were collected and stored in ethically approved tissue banks. One hundred seventy-four prostate cancer tissue samples and 10 normal tissues were marked on standard hematoxylin-eosin (HE) sections, punched out of the paraffin blocks and inserted into a recipient block using tissue arrayer instruments. Immunohistochemistry and RT-PCR were employed to detect TMPRSS2:ERG fusion gene. ERG was highly expressed in the nuclei of endothelial cells of vessels and weak cytoplasmic staining was occasionally observed. ERG positive staining was present in 14.9 % (26/174) of the tumor samples in microarray. All benign prostate samples were found to be negative. RT-PCR results revealed that 11.1 % (15/135) were TMPRSS2:ERG fusion positive. Altogether, there was a good agreement of ERG immunostaining with the presence of TMPRSS2:ERG. However, no correlation was observed between ERG expression and age, Gleason score, stage, surgical margin, and seminal vesicle involvement in Chinese patients. In the present study, we identified a high correlation between ERG expression and ERG TMPRSS2:ERG, with 100 % sensitivity and 88.9 % specificity. The expression level of ERG was unrelated to the age, Gleason score, stage, surgical margin, and seminal vesicle involvement. Therefore, the association between ERG expression and prostate cancer based on Chinese population should be further investigated in the future.
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