ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Inflammation as a mediating pathway between social defeat and mental health in humans: A systematic review.Translational psychiatry · 2026Pooled it
- Microglia associated research in depression: an exploratory trends analysis.Frontiers in aging neuroscience · 2026Pooled it
- Glucocorticoid resistance and β2-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: A systematic review across species.Neuroscience and biobehavioral reviews · 2021Pooled it
- Sickness and the Social Brain: Love in the Time of COVID.Frontiers in psychiatry · 2021Pooled it
- Perceived Discrimination and Immunological Aging: A Systematic Review of Cellular and Molecular Markers.Biopsychosocial science and medicinePooled it
- Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder.Frontiers in immunology · 2018Trial
- Pro-inflammatory markers interact with spontaneous theta oscillations to predict depression among adolescents.Brain, behavior, and immunity · 2026Article
- Repeated social defeat causes bone loss from mouse femur.Brain, behavior, & immunity - health · 2026Article
- Review
- Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis.Brain and behavior · 2026Article
- Environmental enrichment as an immunostimulant for rainbow trout aquaculture.Scientific reports · 2026Article
- A genetic study of immunity in depression and interactions with childhood maltreatment.Translational psychiatry · 2026Article
- Review
- Peripheral inflammation mediates the relationship between early life stress and alcohol use.Psychopharmacology · 2026Article
- Convergent thyroid-ATPase interactions regulate collective behavior in Danionella.Cell reports · 2026Article
- Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Frontiers in cellular neuroscience · 2026Review
- Persistent priming of hypothalamic microglia is associated with sensitization of the hypothalamic-pituitary-adrenal axis to acute stress, hyperactivity and behavioral response disruption in male rats.Frontiers in immunology · 2026Article
- The lactate-HCAR1 axis in exercise psychiatry: a candidate mechanism linking bone marrow-brain immunity to inflammation-related depression.Frontiers in psychiatry · 2026Review
- Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes.Molecular psychiatry · 2025Article
- Narrating the psychoneuroimmunomodulatory properties of serotonin 5-HTActa neuropsychiatrica · 2025Review
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mounting evidence indicates that proinflammatory signaling in the brain affects mood, cognition, and behavior and is linked with the etiology of psychiatric disorders, including anxiety and depression. The purpose of this review is to focus on stress-induced bidirectional communication pathways between the central nervous system (CNS) and peripheral immune system that converge to promote a heightened neuroinflammatory environment. These communication pathways involve sympathetic outflow from the brain to the peripheral immune system that biases hematopoietic stem cells to differentiate into a glucocorticoid-resistant and primed myeloid lineage immune cell. In conjunction, microglia-dependent neuroinflammatory events promote myeloid cell trafficking to the brain that reinforces stress-related behavior, and is argued to play a role in stress-related psychiatric disorders. We will discuss evidence implicating a key role for endothelial cells that comprise the blood-brain barrier in propagating peripheral-to-central immune communication. We will also discuss novel neuron-to-glia communication pathways involving endogenous danger signals that have recently been argued to facilitate neuroinflammation under various conditions, including stress. These findings help elucidate the complex communication that occurs in response to stress and highlight novel therapeutic targets against the development of stress-related psychiatric disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.