ArticleNature communications2016
Specific frontal neural dynamics contribute to decisions to check.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03483233 (Neural Bases of the Check Process), which is not on this map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neural Bases of the Check Process
Who cites it
53 citing papers in PubMed.
- Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.Communications biology · 2026Article
- Active disambiguation guides inferring controllability and cause in social interactions.Nature communications · 2025Article
- Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway.Science advances · 2025Article
- Dorsal raphe nucleus controls motivation-state transitions in monkeys.Science advances · 2025Article
- Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning.bioRxiv : the preprint server for biology · 2025Article
- Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A distributed subcortical circuit linked to instrumental information-seeking about threat.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Emotions and individual differences shape human foraging under threat.Nature. Mental health · 2025Article
- Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Goal commitment is supported by vmPFC through selective attention.Nature human behaviour · 2024Article
- General mechanisms of task engagement in the primate frontal cortex.Nature communications · 2024Article
- Dissociable representations of decision variables within subdivisions of macaque orbitofrontal and ventrolateral frontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Curiosity: primate neural circuits for novelty and information seeking.Nature reviews. Neuroscience · 2024Review
- Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys.Frontiers in neuroscience · 2024Article
- Debates on the dorsomedial prefrontal/dorsal anterior cingulate cortex: insights for future research.Brain : a journal of neurology · 2023Review
- Dissecting the neurocomputational bases of patch-switching.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Differential Weights of Motivational and Task Performance Measures on Medial and Lateral Frontal Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dissociation and integration of outcome and state uncertainty signals in cognitive control.Cognitive, affective & behavioral neuroscience · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curiosity and information seeking potently shapes our behaviour and are thought to rely on the frontal cortex. Yet, the frontal regions and neural dynamics that control the drive to check for information remain unknown. Here we trained monkeys in a task where they had the opportunity to gain information about the potential delivery of a large bonus reward or continue with a default instructed decision task. Single-unit recordings in behaving monkeys reveal that decisions to check for additional information first engage midcingulate cortex and then lateral prefrontal cortex. The opposite is true for instructed decisions. Importantly, deciding to check engages neurons also involved in performance monitoring. Further, specific midcingulate activity could be discerned several trials before the monkeys actually choose to check the environment. Our data show that deciding to seek information on the current state of the environment is characterized by specific dynamics of neural activity within the prefrontal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.