ArticleScientific reports2016
Flow of Red Blood Cells in Stenosed Microvessels.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- From Clogging Mitigation to Clogging Acceleration: Particle Deposition Under Oscillatory Flow in Microfluidic Porous Media.Transport in porous media · 2026Article
- Device-Oriented CFD Comparison of Rectangular and Circular Microchannels with Single and Double Asymmetric Stenoses Under Identical Operating Conditions.Bioengineering (Basel, Switzerland) · 2025Article
- The volume of healthy red blood cells is optimal for advective oxygen transport in arterioles.Biophysical journal · 2024Article
- Numerical analysis of blood flow through stenosed microvessels using a multi-phase model.Heliyon · 2024Article
- Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue.Biophysical reviews · 2023Review
- Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation.Scientific reports · 2021Article
- Effect of Temperature and Flow Rate on the Cell-Free Area in the Microfluidic Channel.Membranes · 2021Article
- Article
- Possible Differential Diagnosis of the Degrees of Rheological Disturbances in Patients with Type 2 Diabetes Mellitus by Dielectrophoresis of Erythrocytes.Journal of personalized medicine · 2020Article
- Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology.Advanced healthcare materials · 2020Review
- Numerical Model for the Determination of Erythrocyte Mechanical Properties and Wall Shear StressFrontiers in physiology · 2019Article
- Article
- Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.Biophysical journal · 2018Article
- The Margination of Particles in Areas of Constricted Blood Flow.Biophysical journal · 2018Article
- Modeling of Biomechanics and Biorheology of Red Blood Cells in Type 2 Diabetes Mellitus.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A computational study is presented on the flow of deformable red blood cells in stenosed microvessels. It is observed that the Fahraeus-Lindqvist effect is significantly enhanced due to the presence of a stenosis. The apparent viscosity of blood is observed to increase by several folds when compared to non-stenosed vessels. An asymmetric distribution of the red blood cells, caused by geometric focusing in stenosed vessels, is observed to play a major role in the enhancement. The asymmetry in cell distribution also results in an asymmetry in average velocity and wall shear stress along the length of the stenosis. The discrete motion of the cells causes large time-dependent fluctuations in flow properties. The root-mean-square of flow rate fluctuations could be an order of magnitude higher than that in non-stenosed vessels. Several folds increase in Eulerian velocity fluctuation is also observed in the vicinity of the stenosis. Surprisingly, a transient flow reversal is observed upstream a stenosis but not downstream. The asymmetry and fluctuations in flow quantities and the flow reversal would not occur in absence of the cells. It is concluded that the flow physics and its physiological consequences are significantly different in micro- versus macrovascular stenosis.
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