ArticleScientific reports2016
ORION: a web server for protein fold recognition and structure prediction using evolutionary hybrid profiles.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
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- Profiles of Natural and Designed Protein-Like Sequences Effectively Bridge Protein Sequence Gaps: Implications in Distant Homology Detection.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Identification of a new regulation pathway of EGFR and E-cadherin dynamics.Scientific reports · 2021Article
- Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2.PLoS computational biology · 2021Article
- PYTHIA: Deep Learning Approach for Local Protein Conformation Prediction.International journal of molecular sciences · 2021Article
- PCPD: Plant cytochrome P450 database and web-based tools for structural construction and ligand docking.Synthetic and systems biotechnology · 2021Article
- Peptides-based vaccine against SARS-Bio-design and manufacturing · 2021Article
- Dickkopf-1: A Promising Target for Cancer Immunotherapy.Frontiers in immunology · 2021Review
- iHyd-LysSite (EPSV): Identifying Hydroxylysine Sites in Protein Using Statistical Formulation by Extracting Enhanced Position and Sequence Variant Feature Technique.Current genomics · 2020Article
- Analysis of Protein Disorder Predictions in the Light of a Protein Structural Alphabet.Biomolecules · 2020Article
- Sonification basedAPL bioengineering · 2020Article
- Putative circumsporozoite protein (CSP) ofGene: X · 2019Article
- Article
- PBxplore: a tool to analyze local protein structure and deformability with Protein Blocks.PeerJ · 2017Article
- TMPL: a database of experimental and theoretical transmembrane protein models positioned in the lipid bilayer.Database : the journal of biological databases and curation · 2017Article
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5 authors.
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Abstract
Protein structure prediction based on comparative modeling is the most efficient way to produce structural models when it can be performed. ORION is a dedicated webserver based on a new strategy that performs this task. The identification by ORION of suitable templates is performed using an original profile-profile approach that combines sequence and structure evolution information. Structure evolution information is encoded into profiles using structural features, such as solvent accessibility and local conformation -with Protein Blocks-, which give an accurate description of the local protein structure. ORION has recently been improved, increasing by 5% the quality of its results. The ORION web server accepts a single protein sequence as input and searches homologous protein structures within minutes. Various databases such as PDB, SCOP and HOMSTRAD can be mined to find an appropriate structural template. For the modeling step, a protein 3D structure can be directly obtained from the selected template by MODELLER and displayed with global and local quality model estimation measures. The sequence and the predicted structure of 4 examples from the CAMEO server and a recent CASP11 target from the 'Hard' category (T0818-D1) are shown as pertinent examples. Our web server is accessible at http://www.dsimb.inserm.fr/ORION/.
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