Evidence map›Paper›PMID 27318855›Full record

Trial reportNutrition (Burbank, Los Angeles County, Calif.)2016

Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study.

Elena J Ladas, Manuela Orjuela, Kristen Stevenson, Peter D Cole, Meiko Lin, Uma H Athale, Luis A Clavell, Jean-Marie Leclerc, Bruno Michon, Marshall A Schorin and 5 more

Registry-linked trialOpen access · greenAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Nutrition (Burbank, Los Angeles County, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04764695 (Evaluation of Body Composition and Nutritional Status in Pediatric Patients With Hematological Malignancies), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04764695 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of Body Composition and Nutritional Status in Pediatric Patients With Hematological Malignancies

TypeinterventionalSponsorUniversidad de SonoraRan2023 to 2024Enrolled38ConditionsChildhood Cancer, Child Malnutrition, Childhood ObesityArmsD2O dilution technique
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Decoding the Implications of Zinc in the Development and Therapy of Leukemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. The evolution of nutritional care in children and young people with acute lymphoblastic leukaemia: a narrative review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Review
  11. Article
  12. Metabolic Implications of Childhood Cancer.Current pediatrics reports · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 3 countries.

Elena J LadasDivision of Pediatric Hematology/Oncology/Stem Cell Transplant, Columbia University Medical Center, New York, New York, USA; Institute of Human Nutrition, Columbia University, New York, New York, USA. Electronic address: ejd14@cumc.columbia.edu.
Manuela OrjuelaDivision of Pediatric Hematology/Oncology/Stem Cell Transplant, Columbia University Medical Center, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA.
Kristen StevensonDana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA.
Peter D ColeAlbert Einstein College of Medicine, Bronx, New York, USA.
Meiko LinTeachers College, Columbia University, New York, New York, USA.
Uma H AthaleDivision of Hematology/Oncology, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada.
Luis A ClavellSan Jorge Children's Hospital, San Juan, Puerto Rico.
Jean-Marie LeclercHematology-Oncology Division, Charles Bruneau Cancer Center, Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada.
Bruno MichonCentre Hospitalier Universitaire de Quebec, Sainte-Foy, Quebec, Canada.
Marshall A SchorinInova Children's Hospital, Falls Church, Virginia, USA.
Jennifer Greene WelchDivision of Pediatric Hematology/Oncology, Hasbro Children's Hospital, Brown University, Providence, RI, USA.
Barbara L AsselinDepartment of Pediatrics, University of Rochester School of Medicine, Golisano Children's Hospital at University of Rochester Medical Center, Rochester, New York, USA.
Stephen E SallanDana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA.
Lewis B SilvermanDana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA.
Kara M KellyDivision of Pediatric Hematology/Oncology/Stem Cell Transplant, Columbia University Medical Center, New York, New York, USA.
Columbia University · USColumbia University Irving Medical Center · USDana-Farber Cancer Institute · USAlbert Einstein College of Medicine · USBoston Children's Hospital · USCentre hospitalier universitaire de Québec · CACentre Hospitalier Universitaire Sainte-Justine · CAHasbro Children's Hospital · USInova Children's Hospital · USMcMaster Children's Hospital · CASan Juan City Hospital · PRUniversity of Rochester Medical Center · US

Funding

Methylation and mutations in RB1 and variants of synthetic folic acid metabolismR01CA192662 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ORJUELA, MANUELA A · 2015 to 2018
$1.5M
NCI NIH HHS R01 CA192662
6 · The paper itself

Abstract

objectiveChildren with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition-related morbidity both during and after therapy. We present the demographic characteristics and nutrient intake at study entry of a prospective cohort in which evaluating dietary intake in children diagnosed with ALL was investigated.

methodsDietary intake data were collected for participants enrolled on the Dana-Farber Cancer Institute ALL Consortium Protocol. Dietary intake was assessed with a food frequency questionnaire and was compared with the dietary reference intake by ALL risk group (standard and high risk).

resultsDietary intake data were collected from 81% of participants (n = 640). We found that 27% of participants were overweight/obese. Intake of total calories and other nutrients exceeded the dietary reference intake in up to 79% of children. This was evident in both risk groups and was pronounced among younger children. For micronutrients, dietary intake of calcium, vitamin D (females only), and zinc differed significantly between patients with standard-risk and those with high-risk ALL.

conclusionsThis study was successful in collecting dietary intake data at the time of cancer diagnosis in a multicenter setting in a pediatric population at high-risk for nutrition-related morbidity. We identified "at-risk" dietary intakes, which vary by sex and ALL risk group; such patients may benefit from future dietary interventions.

Indexed as

DietEnergy IntakeAdolescentChildChild, PreschoolCohort StudiesFemaleHumansInfantMaleNutritional StatusPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesRecommended Dietary AllowancesAcute lymphoblastic leukemiaDietary intakeMicronutrient intake: macronutrient intakeNutritional statusObesityPediatric oncology

Identifiers

PMID27318855
PMCPMC5572566
OpenAlexW2330424056

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.