ArticlePflugers Archiv : European journal of physiology2016
Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes.
Article in Pflugers Archiv : European journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- The Physiological Significance of TRP and Piezo Channels as Physical Stimulus Sensors in Brown Adipocytes.Cells · 2026Review
- Metabolomic profiling reveals dynamic lipid reprogramming during adipogenesis in 3T3-L1 cells.Frontiers in molecular biosciences · 2026Article
- Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.The journal of physiological sciences : JPS · 2022Article
- The role of TRPV channels in osteoporosis.Molecular biology reports · 2022Review
- Uncoupling protein 1-independent effects of eicosapentaenoic acid in brown adipose tissue of diet-induced obese female mice.The Journal of nutritional biochemistry · 2021Article
- Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.Cell cycle (Georgetown, Tex.) · 2021Article
- Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue.International journal of biological sciences · 2021Review
- Involvement of TRP Channels in Adipocyte Thermogenesis: An Update.Frontiers in cell and developmental biology · 2021Review
- Review
- Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia.Journal of cellular and molecular medicine · 2020Article
- A Transcriptomic Analysis Reveals Novel Patterns of Gene Expression During 3T3-L1 Adipocyte Differentiation.Frontiers in molecular biosciences · 2020Article
- The role of adipose TRP channels in the pathogenesis of obesity.Journal of cellular physiology · 2019Review
- Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity.International journal of molecular sciences · 2019Review
- Small molecules for fat combustion: targeting obesity.Acta pharmaceutica Sinica. B · 2019Review
- Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.Frontiers in physiology · 2019Review
- TRPV2-induced CaCell communication and signaling : CCS · 2018Article
- Lipophilic Chemicals from Diesel Exhaust Particles Trigger Calcium Response in Human Endothelial Cells via Aryl Hydrocarbon Receptor Non-Genomic Signalling.International journal of molecular sciences · 2018Article
- Dietary menthol-induced TRPM8 activation enhances WAT "browning" and ameliorates diet-induced obesity.Oncotarget · 2017Article
- Involvement of thermosensitive TRP channels in energy metabolism.The journal of physiological sciences : JPS · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient receptor potential vanilloid 2 (TRPV2) acts as a Ca(2+)-permeable non-selective cation channel that has been reported to be sensitive to temperature, mechanical force, and some chemicals. We recently showed that TRPV2 is critical for maintenance of the thermogenic function of brown adipose tissue in mice. However, the involvement of TRPV2 in the differentiation of brown adipocytes remains unexplored. We found that the expression of TRPV2 was dramatically increased during the differentiation of brown adipocytes. Non-selective TRPV2 agonists (2-aminoethoxydiphenyl borate and lysophosphatidylcholine) inhibited the differentiation of brown adipocytes in a dose-dependent manner during the early stage of differentiation of brown adipocytes. The inhibition was rescued by a TRPV2-selective antagonist, SKF96365 (SKF). Mechanical force, which activates TRPV2, also inhibited the differentiation of brown adipocytes in a strength-dependent manner, and the effect was reversed by SKF. In addition, the inhibition of adipocyte differentiation by either TRPV2 ligand or mechanical stimulation was significantly smaller in the cells from TRPV2KO mice. Moreover, calcineurin inhibitors, cyclosporine A and FK506, partially reversed TRPV2 activation-induced inhibition of brown adipocyte differentiation. Thus, we conclude that TRPV2 might be involved in the modulation of brown adipocyte differentiation partially via a calcineurin pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.