ArticleSchizophrenia research2016
Elevated plasma F2-isoprostane levels in schizophrenia.
Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Antioxidant Enzymes and Weight Gain in Drug-naive First-episode Schizophrenia Patients Treated with Risperidone for 12 Weeks: A Prospective Longitudinal Study.Current neuropharmacology · 2022Trial
- Improving Healthy Living in Residential Care Facilities: Feasibility, Acceptability, and Appropriateness of Implementing a Multicomponent Intervention for Diabetes Risk Reduction in Adults with Serious Mental Illnesses.Administration and policy in mental health · 2022Article
- Associations between inflammatory marker profiles and neurocognitive functioning in people with schizophrenia and non-psychiatric comparison subjects.Journal of psychiatric research · 2022Article
- The Relationship between FAntioxidants (Basel, Switzerland) · 2022Article
- Endotoxin Tolerance in Abdominal Aortic Aneurysm Macrophages, In Vitro: A Case-Control Study.Antioxidants (Basel, Switzerland) · 2020Article
- Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population.Neuropsychiatric disease and treatment · 2020Article
- Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology.Frontiers in psychiatry · 2020Article
- High prevalence and adverse health effects of loneliness in community-dwelling adults across the lifespan: role of wisdom as a protective factor.International psychogeriatrics · 2019Article
- A novel biomarker of cardiometabolic pathology in schizophrenia?Journal of psychiatric research · 2019Article
- Assessment of 3-dimensional wisdom in schizophrenia: Associations with neuropsychological functions and physical and mental health.Schizophrenia research · 2019Article
- Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects.Schizophrenia research · 2019Article
- Clinical Correlates of Insulin Resistance in Chronic Schizophrenia: Relationship to Negative Symptoms.Frontiers in psychiatry · 2019Article
- Sleep Disturbances and Inflammatory Biomarkers in Schizophrenia: Focus on Sex Differences.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
- Abnormal levels of vascular endothelial biomarkers in schizophrenia.European archives of psychiatry and clinical neuroscience · 2018Article
- Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients.Translational psychiatry · 2018Article
- Avoidance of accelerated aging in schizophrenia?: Clinical and biological characterization of an exceptionally high functioning individual.Schizophrenia research · 2018Article
- DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia.Schizophrenia research · 2018Article
- Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions.Schizophrenia bulletin · 2018Review
- Loneliness in schizophrenia: Construct clarification, measurement, and clinical relevance.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundSchizophrenia is one of the most disabling psychiatric disorders with increased morbidity and mortality. Both schizophrenia and oxidative stress have been associated with accelerated aging. Previous studies found increased oxidative stress in individuals with schizophrenia, though only one study measured F2-isoprostanes and did so in urine. To our knowledge, the present study is the first to assess plasma F2-isoprostane levels, the putative gold standard measure of systemic oxidative stress in vivo, in schizophrenia.
methodsWe compared plasma F2-isoprostane levels in 134 stable outpatients with schizophrenia and 120 age- and gender-matched healthy comparison (HC) subjects. Sociodemographic and clinical data were collected in both groups.
resultsPlasma F2-isoprostane levels were significantly higher in the schizophrenia group than in the HC group. Women had higher F2-isoprostane levels compared to men, and those with higher body mass index (BMI) had higher levels, within each group. F2-isoprostane levels correlated with BMI, physical functioning, and medical comorbidity but not with severity of psychopathology or executive function. Linear models showed significant effects of diagnosis, gender, and BMI on F2-isoprostane levels, but no interactions. DISCUSSION: Our finding of increased oxidative stress in schizophrenia is consistent with reports of increased morbidity and mortality as well as accelerated aging in schizophrenia. The significant associations between F2-isoprostane levels and both gender and BMI warrant further study.
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