Evidence map›Paper›PMID 27318138›Full record

ArticleNeurobiology of aging2016

Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy.

Aida Suárez-González, Manja Lehmann, Timothy J Shakespeare, Keir X X Yong, Ross W Paterson, Catherine F Slattery, Alexander J M Foulkes, Gil D Rabinovici, Eulogio Gil-Néciga, Florinda Roldán-Lora and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019
    Article
  9. Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Aida Suárez-GonzálezDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK; Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain. Electronic address: aida.gonzalez@ucl.ac.uk.
Manja LehmannDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK; Memory and Aging Center, University of California San Francisco, San Francisco, California, USA.
Timothy J ShakespeareDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Keir X X YongDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Ross W PatersonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Catherine F SlatteryDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Alexander J M FoulkesDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Gil D RabinoviciMemory and Aging Center, University of California San Francisco, San Francisco, California, USA.
Eulogio Gil-NécigaDepartment of Neurology, University Hospital Virgen del Rocio, Seville, Spain.
Florinda Roldán-LoraDepartment of Radiology, University Hospital Virgen del Rocio, Seville, Spain.
Jonathan M SchottDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Nick C FoxDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Sebastian J CrutchDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
UK Dementia Research Institute · GBHospital Universitario Virgen del Rocío · ESUniversity College London · GBUniversity Memory and Aging Center · USUniversity of California, San Francisco · US

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Early Age-of-Onset AD: Clinical Heterogeneity and Network DegenerationR01AG045611 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RABINOVICI, GIL DAN · 2014 to 2018
$3.1M
NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG045611The Dunhill Medical Trust R337/0214
6 · The paper itself

Abstract

Age at onset (AAO) has been shown to influence the phenotype of Alzheimer's disease (AD), but how it affects atypical presentations of AD remains unknown. Posterior cortical atrophy (PCA) is the most common form of atypical AD. In this study, we aimed to investigate the effect of AAO on cortical thickness and cognitive function in 98 PCA patients. We used Freesurfer (v5.3.0) to compare cortical thickness with AAO both as a continuous variable, and by dichotomizing the groups based on median age (58 years). In both the continuous and dichotomized analyses, we found a pattern suggestive of thinner cortex in precuneus and parietal areas in earlier-onset PCA, and lower cortical thickness in anterior cingulate and prefrontal cortex in later-onset PCA. These cortical thickness differences between PCA subgroups were consistent with earlier-onset PCA patients performing worse on cognitive tests involving parietal functions. Our results provide a suggestion that AAO may not only affect the clinico-anatomical characteristics in AD but may also affect atrophy patterns and cognition within atypical AD phenotypes.

Indexed as

CognitionAgedAge of OnsetAgingAlzheimer DiseaseAtrophyCerebral CortexFemaleHumansMaleMiddle AgedNeuropsychological TestsAge at onsetAtypical Alzheimer diseaseCortical thicknessNeuroimagingPosterior cortical atrophy

Identifiers

PMID27318138
PMCPMC4926954
OpenAlexW2345098872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.