ArticleNeurobiology of aging2016
Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Kv4.2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ventral posterolateral and ventral posteromedial thalamocortical neurons have distinct physiological properties.Journal of neurophysiology · 2023Article
- Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes.Alzheimer's research & therapy · 2023Article
- Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus.Brain research bulletin · 2022Review
- Secondary thalamic neuroinflammation after focal cortical stroke and traumatic injury mirrors corticothalamic functional connectivity.The Journal of comparative neurology · 2022Article
- Article
- The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.Brain : a journal of neurology · 2022Article
- Article
- Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice.Science translational medicine · 2021Article
- Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.Molecular neurodegeneration · 2020Article
- Association of β-Amyloid Burden With Sleep Dysfunction and Cognitive Impairment in Elderly Individuals With Cognitive Disorders.JAMA network open · 2019Article
- Corticothalamic network dysfunction and Alzheimer's disease.Brain research · 2019Review
- Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.International journal of molecular sciences · 2017Review
- Epileptic activity in Alzheimer's disease: causes and clinical relevance.The Lancet. Neurology · 2017Review
- Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy.NeuroImage. Clinical · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
Alzheimer's disease is associated with cognitive decline and seizures. Growing evidence indicates that seizures contribute to cognitive deficits early in disease, but how they develop and impact cognition are unclear. To investigate potential mechanisms, we studied a mouse model that overexpresses mutant human amyloid precursor protein with high levels of amyloid beta (Aβ). These mice develop generalized epileptiform activity, including nonconvulsive seizures, consistent with alterations in corticothalamic network activity. Amyloid precursor protein mice exhibited reduced activity marker expression in the reticular thalamic nucleus, a key inhibitory regulatory nucleus, and increased activity marker expression in downstream thalamic relay targets that project to cortex and limbic structures. Slice recordings revealed impaired cortical inputs to the reticular thalamic nucleus that may contribute to corticothalamic dysfunction. These results are consistent with our findings of impaired sleep maintenance in amyloid precursor protein mice. Finally, the severity of sleep impairments predicted the severity of deficits in Morris water maze, suggesting corticothalamic dysfunction may relate to hippocampal dysfunction, and may be a pathophysiological mechanism underlying multiple behavioral and cognitive alterations in Alzheimer's disease.
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