ArticleClinical and experimental immunology2016
H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease.
Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective.Experimental & molecular medicine · 2024Pooled it
- Recent advances and evolving concepts in Still's disease.Nature reviews. Rheumatology · 2024Review
- Article
- COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment.Antioxidants (Basel, Switzerland) · 2022Article
- Activation mechanisms of monocytes/macrophages in adult-onset Still disease.Frontiers in immunology · 2022Review
- Adult-onset Still's disease: A disease at the crossroad of innate immunity and autoimmunity.Frontiers in medicine · 2022Review
- Increased Lipid Peroxidation May Be Linked to Ferritin Levels Elevation in Adult-Onset Still's Disease.Biomedicines · 2021Article
- The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile.Scientific reports · 2021Observational
- An Update on the Pathogenic Role of Macrophages in Adult-Onset Still's Disease and Its Implication in Clinical Manifestations and Novel Therapeutics.Journal of immunology research · 2021Review
- NCOA4-Mediated Ferritinophagy: A Vicious Culprit in COVID-19 Pathogenesis?Frontiers in molecular biosciences · 2021Article
- COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy.Immunologic research · 2020Review
- Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations.Scientific reports · 2020Article
- Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review.Chinese medical journal · 2019Review
- Macrophage activation syndrome and pulmonary arterial hypertension in a patient with adult-onset Still disease: A case report.Medicine · 2019Article
- Long-Term Retention Rate of Anakinra in Adult Onset Still's Disease and Predictive Factors for Treatment Response.Frontiers in pharmacology · 2019Article
- H-ferritin and proinflammatory cytokines are increased in the bone marrow of patients affected by macrophage activation syndrome.Clinical and experimental immunology · 2018Article
- Macrophage activation syndrome in Still's disease: analysis of clinical characteristics and survival in paediatric and adult patients.Clinical rheumatology · 2017Article
- Observational
- Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers.BMC medicine · 2016Article
- Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm.Frontiers in immunologyReview
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein composed of 24 subunits, heavy (H) subunits and light (L) subunits. The ferritin enriched in L subunits (L-ferritin) and the ferritin enriched in H subunits (H-ferritin) may be observed in different tissues. In this work, we aimed to investigate the skin expression of both H-and L-ferritin and the number of macrophages expressing these molecules from AOSD patients with persistent cutaneous lesions. We observed an increased expression of H-ferritin in the skin, associated with an infiltrate in the biopsies obtained from persistent cutaneous lesions of AOSD patients. Furthermore, a positive correlation between H-ferritin skin levels as well as the number of CD68(+) /H-ferritin(+) cells and the multi-visceral involvement of the disease was observed. Our data showed an increased expression of H-ferritin in the skin of AOSD patients, associated with a strong infiltrate of CD68(+) /H-ferritin(+) cells. Furthermore, a correlation between the levels of H-ferritin as well as of the number of CD68(+) /H-ferritin(+) cells and the multi-visceral involvement of the disease was observed.
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