ArticleG3 (Bethesda, Md.)2016
Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Genome-wide association studies identify new candidate genes and tissues underlying resistance to a natural toxin in drosophilids.G3 (Bethesda, Md.) · 2026Article
- Insecticide Resistance Alters Oviposition Preference inEcology and evolution · 2026Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution.PLoS biology · 2023Article
- Transposable elements and xenobiotic resistance.Frontiers in insect science · 2023Review
- The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors.BMC biology · 2022Article
- Discovery of malathion resistance QTL in Drosophila melanogaster using a bulked phenotyping approach.G3 (Bethesda, Md.) · 2022Article
- A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population.Molecular biology and evolution · 2022Article
- Article
- Article
- Ocular Albinism Type 1 Regulates Deltamethrin Tolerance inFrontiers in physiology · 2019Article
- Structural Variants and Selective Sweep Foci Contribute to Insecticide Resistance in theG3 (Bethesda, Md.) · 2018Article
- Signatures of Insecticide Selection in the Genome ofG3 (Bethesda, Md.) · 2018Article
- Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations.Scientific reports · 2018Article
- The road less traveled: from genotype to phenotype in flies and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Charting the genotype-phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Insights into DDT Resistance from theGenetics · 2017Article
- Multiple P450s and Variation in Neuronal Genes Underpins the Response to the Insecticide Imidacloprid in a Population of Drosophila melanogaster.Scientific reports · 2017Article
- Does resistance really carry a fitness cost?Current opinion in insect science · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scans of the Drosophila melanogaster genome have identified organophosphate resistance loci among those with the most pronounced signature of positive selection. In this study, the molecular basis of resistance to the organophosphate insecticide azinphos-methyl was investigated using the Drosophila Genetic Reference Panel, and genome-wide association. Recently released full transcriptome data were used to extend the utility of the Drosophila Genetic Reference Panel resource beyond traditional genome-wide association studies to allow systems genetics analyses of phenotypes. We found that both genomic and transcriptomic associations independently identified Cyp6g1, a gene involved in resistance to DDT and neonicotinoid insecticides, as the top candidate for azinphos-methyl resistance. This was verified by transgenically overexpressing Cyp6g1 using natural regulatory elements from a resistant allele, resulting in a 6.5-fold increase in resistance. We also identified four novel candidate genes associated with azinphos-methyl resistance, all of which are involved in either regulation of fat storage, or nervous system development. In Cyp6g1, we find a demonstrable resistance locus, a verification that transcriptome data can be used to identify variants associated with insecticide resistance, and an overlap between peaks of a genome-wide association study, and a genome-wide selective sweep analysis.
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