Evidence map›Paper›PMID 27317750›Full record

ArticleJournal of leukocyte biology2016

Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor.

D M Elizondo, T E Andargie, K M Marshall, A M Zariwala, M W Lipscomb

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Macrophage Functions in Psoriasis: Lessons from Mouse Models.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. IL-10 producing CD8Journal of leukocyte biology · 2019
    Article
  14. EGFL7 reduces CNS inflammation in mouse.Nature communications · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D M ElizondoDepartment of Biology, Howard University, Washington, DC, USA.
T E AndargieDepartment of Biology, Howard University, Washington, DC, USA.
K M MarshallDepartment of Biology, Howard University, Washington, DC, USA.
A M ZariwalaDepartment of Biology, Howard University, Washington, DC, USA.
M W LipscombDepartment of Biology, Howard University, Washington, DC, USA michael.lipscomb@howard.edu.
Howard University · US

Funding

Crosstalk and the cytoskeleton in dendritic cell antigen presentationSC2GM103741 · NIGMS · HOWARD UNIVERSITY · PI LIPSCOMB, MICHAEL W · 2015 to 2017
$441k
NIGMS NIH HHS SC2 GM103741
6 · The paper itself

Abstract

ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs partially governs antigen-presentation capacities to responder CD4

Indexed as

ADAM ProteinsAnimalsAntibodies, NeutralizingCD4-Positive T-LymphocytesCell DivisionCytokinesDendritic CellsGene Knockdown TechniquesIntegrin alphaVbeta3Lymphocyte ActivationLymphocyte Culture Test, MixedMiceMice, Inbred C57BLMice, Inbred NODNerve Tissue ProteinsOvalbuminAdam23 protein, mouseADAM ProteinsAntibodies, NeutralizingCytokinesIntegrin alphaVbeta3Nerve Tissue ProteinsOVA 323-339OvalbuminPeptide FragmentsRNA, Small Interferingadhesionantigen presentationcostimulationcytoskeletondisintegrin

Identifiers

PMID27317750
PMCPMC6608068
OpenAlexW2437193757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.