Evidence map›Paper›PMID 27317706›Full record

Trial reportBritish journal of anaesthesia2016

Sumatriptan improves postoperative quality of recovery and reduces postcraniotomy headache after cranial nerve decompression.

L Venkatraghavan, L Li, T Bailey, P H Manninen, M Tymianski

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01632657 (Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01632657 nacompletednot on this map

Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy

TypeinterventionalSponsorUniversity Health Network, TorontoRan2012 to 2019Enrolled40ConditionsPostoperative Quality of Recovery, Postoperative Migrainous HeadacheArmsSumatriptan, Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

L VenkatraghavanDepartment of Anesthesia lashmi.venkatraghavan@uhn.on.ca.
L LiDepartment of Anesthesia Present address: Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee, UK.
T BaileyDepartment of Anesthesia Present address: Department of Anaesthesia, Waikato Hospital, Hamilton 3204, New Zealand.
P H ManninenDepartment of Anesthesia.
M TymianskiDepartment of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicrovascular decompression (MVD) is a surgical treatment for cranial nerve disorders via a small craniotomy. The postoperative pain of this procedure can be classified as surgical site somatic pain and postcraniotomy headache similar in nature to a migraine, including its association with photophobia, nausea, and vomiting. This headache can be difficult to treat and can impact on postoperative recovery. Sumatriptan is used to treat migraine-like headaches in various settings. This single-centre randomized controlled trial investigated whether postoperative administration of sumatriptan after MVD surgery impacts the quality of postoperative recovery.

methodsFifty patients who complained of postoperative headache after MVD were randomized to receive an s.c. injection of sumatriptan (6 mg) or saline. The primary outcome was quality of recovery as measured by the Quality of Recovery-40 (QoR-40) score at 24 h.

resultsThe QoR-40 scores were significantly higher in the sumatriptan group (median 184; interquartile range 169-196) than in the placebo group (133; 119-155; P<0.01), suggesting higher quality of recovery. The sumatriptan group also had significantly lower headache scores at 4, 12, and 24 h. There were no significant differences in other secondary outcomes.

conclusionsUse of sumatriptan improved the quality of recovery as measured by the QoR-40 and reduction of headache at 24 h after surgery. Sumatriptan is a useful alternative treatment for postcraniotomy headache. The mechanism remains unknown but could be related to reduction in headache, mood modulation, or both, mediated by a serotonin effect. CLINICAL

trial registrationNCT01632657.

Indexed as

AdolescentAdultAgedAged, 80 and overCranial Nerve DiseasesCranial NervesDouble-Blind MethodFemaleHeadacheHumansMaleMicrovascular Decompression SurgeryMiddle AgedPostoperative ComplicationsPostoperative PeriodSumatriptanSumatriptanVasoconstrictor Agentsanalgesiaheadachemicrovascular decompression surgeryrecovery, postoperativesumatriptan

Identifiers

PMID27317706
PMCPMC4913404
OpenAlexW2433354596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.