ArticleAmerican journal of physiology. Lung cellular and molecular physiology2016
A new experimental model of acid- and endotoxin-induced acute lung injury in rats.
Article in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension.Animal models and experimental medicine · 2026Article
- Priming Mesenchymal Stem Cells with Lipopolysaccharide Boosts the Immunomodulatory and Regenerative Activity of Secreted Extracellular Vesicles.Pharmaceutics · 2024Article
- Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model.Small science · 2024Article
- Translational medicine for acute lung injury.Journal of translational medicine · 2024Review
- Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury.Frontiers in immunology · 2024Review
- Comparison of Pulmonary and Extrapulmonary Models of Sepsis-Associated Acute Lung Injury.Physiological research · 2023Article
- Modeling of Chronic Lung Inflammation in Rats by Repeated Intratracheal Administration of LPS.Bulletin of experimental biology and medicine · 2022Article
- Ingredients of Jelly Products Affect Aspiration-Related Pulmonary Inflammation; in an Animal Study.Dysphagia · 2021Article
- Sex-Related Differences in Murine Models of Chemically Induced Pulmonary Fibrosis.International journal of molecular sciences · 2021Article
- Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages.Journal of inflammation research · 2021Article
- Comparison of direct and indirect models of early induced acute lung injury.Intensive care medicine experimental · 2020Article
- Article
- Effects of nebulized antithrombin and heparin on inflammatory and coagulation alterations in an acute lung injury model in rats.Journal of thrombosis and haemostasis : JTH · 2020Article
- Ameliorative effects of silymarin on HCl-induced acute lung injury in rats; role of the Nrf-2/HO-1 pathway.Iranian journal of basic medical sciences · 2019Article
- The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution.Respiratory research · 2018Article
- Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages.Respiratory research · 2017Article
- Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injury.Thrombosis and haemostasis · 2017Article
- Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury.Respiratory research · 2017Article
- Preventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury.Scientific reports · 2017Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of the animal models of acute lung injury (ALI) are focused on the acute phase. This limits the studies of the mechanisms involved in later phases and the effects of long-term treatments. Thus the goal of this study was to develop an experimental ALI model of aspiration pneumonia, in which diffuse alveolar damage continues for 72 h. Rats were intratracheally instilled with one dose of HCl (0.1 mol/l) followed by another instillation of one dose of LPS (0, 10, 20, 30, or 40 μg/g body weight) 2 h later, which models aspiration of gastric contents that progresses to secondary lung injury from bacteria or bacterial products. The rats were euthanized at 24, 48, and 72 h after the last instillation. The results showed that HCl and LPS at all doses caused activation of inflammatory responses, increased protein permeability and apoptosis, and induced mild hypoxemia in rat lungs at 24 h postinstillation. However, this lung damage was present at 72 h only in rats receiving HCl and LPS at the doses of 30 and 40 μg/g body wt. Mortality (∼50%) occurred in the first 48 h and only in the rats treated with HCl and LPS at the highest dose (40 μg/g body wt). In conclusion, intratracheal instillation of HCl followed by LPS at the dose of 30 μg/g body wt results in severe diffuse alveolar damage that continues at least 72 h. This rat model of aspiration pneumonia-induced ALI will be useful for testing long-term effects of new therapeutic strategies in ALI.
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