ArticleThe Plant cell2016
Biosynthesis of 8-O-Methylated Benzoxazinoid Defense Compounds in Maize.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 126 citations in OpenAlex.
- Plant Volatile Methyl Salicylate Primes Wheat Defense Against the Grain Aphid by Altering the Synthesis of Defense Metabolites.Plant, cell & environment · 2026Article
- Evolutionary divergence and regulatory landscapes of benzoxazinoid metabolism in monocot crops.Plant cell reports · 2026Review
- Integration of the D-Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Three Closely Related Spodoptera Species Similarly Affect Gene Expression and Phytohormone Levels but Differentially Induce Volatile Emissions in Maize.Plant, cell & environment · 2026Article
- Arbuscular Mycorrhizal Fungi Mitigate Drought-Enhanced Herbivore Performance in Maize.Plant, cell & environment · 2026Article
- Genetic Divergence and Functional Significance of Bioactive Compounds in Rice and Barley: Implications for Biofortification and Human Health.International journal of molecular sciences · 2025Review
- Review
- Plant-aphid interactions: recent trends in plant resistance to aphids.Stress biology · 2025Review
- Benzoxazinoids Biosynthetic Gene Cluster Identification and Expression Analysis in Maize under Biotic and Abiotic Stresses.International journal of molecular sciences · 2024Article
- Genome-Wide Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2024Article
- The Function of Root Exudates in the Root Colonization by Beneficial Soil Rhizobacteria.Biology · 2024Review
- Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Inactivation of RPX1 in Arabidopsis confers resistance to Plutella xylostella through the accumulation of the homoterpene DMNT.Plant, cell & environment · 2023Article
- Genetic Variation, DIMBOA Accumulation, and Candidate Gene Identification in Maize Multiple Insect-Resistance.International journal of molecular sciences · 2023Article
- Stressing the importance of plant specialized metabolites: omics-based approaches for discovering specialized metabolism in plant stress responses.Frontiers in plant science · 2023Review
- Functional diversity and metabolic engineering of plant-specialized metabolites.Life metabolism · 2022Review
- The transcription factor TaMYB31 regulates the benzoxazinoid biosynthetic pathway in wheat.Journal of experimental botany · 2022Article
- Plant biosynthetic gene clusters in the context of metabolic evolution.Natural product reports · 2022Review
- Phenolic sucrose esters: evolution, regulation, biosynthesis, and biological functions.Plant molecular biology · 2022Review
- Genetic Resources of Cereal Crops for Aphid Resistance.Plants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzoxazinoids are important defense compounds in grasses. Here, we investigated the biosynthesis and biological roles of the 8-O-methylated benzoxazinoids, DIM2BOA-Glc and HDM2BOA-Glc. Using quantitative trait locus mapping and heterologous expression, we identified a 2-oxoglutarate-dependent dioxygenase (BX13) that catalyzes the conversion of DIMBOA-Glc into a new benzoxazinoid intermediate (TRIMBOA-Glc) by an uncommon reaction involving a hydroxylation and a likely ortho-rearrangement of a methoxy group. TRIMBOA-Glc is then converted to DIM2BOA-Glc by a previously described O-methyltransferase BX7. Furthermore, we identified an O-methyltransferase (BX14) that converts DIM2BOA-Glc to HDM2BOA-Glc. The role of these enzymes in vivo was demonstrated by characterizing recombinant inbred lines, including Oh43, which has a point mutation in the start codon of Bx13 and lacks both DIM2BOA-Glc and HDM2BOA-Glc, and Il14H, which has an inactive Bx14 allele and lacks HDM2BOA-Glc in leaves. Experiments with near-isogenic maize lines derived from crosses between B73 and Oh43 revealed that the absence of DIM2BOA-Glc and HDM2BOA-Glc does not alter the constitutive accumulation or deglucosylation of other benzoxazinoids. The growth of various chewing herbivores was not significantly affected by the absence of BX13-dependent metabolites, while aphid performance increased, suggesting that DIM2BOA-Glc and/or HDM2BOA-Glc provide specific protection against phloem feeding insects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.