Evidence map›Paper›PMID 27317656›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice.

Gaiqing Wang, Anatol Manaenko, Anwen Shao, Yibo Ou, Peng Yang, Enkhjargal Budbazar, Derek Nowrangi, John H Zhang, Jiping Tang

Expression of concernOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Regulation of mitochondrial iron homeostasis in tumor cells.Molecular medicine (Cambridge, Mass.) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Gaiqing Wang1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Anatol Manaenko1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Anwen Shao1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Yibo Ou1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Peng Yang1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Enkhjargal Budbazar1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Derek Nowrangi1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
John H Zhang1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Jiping Tang1 Department of Physiology, Loma Linda University, Loma Linda, CA, USA.
Loma Linda University · USShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heme-degradation after erythrocyte lysis plays an important role in the pathophysiology of intracerebral hemorrhage. Low-density lipoprotein receptor-related protein-1 is a receptor expressed predominately at the neurovascular interface, which facilitates the clearance of the hemopexin and heme complex. In the present study, we investigated the role of low-density lipoprotein receptor-related protein-1 in heme removal and neuroprotection in a mouse model of intracerebral hemorrhage. Endogenous low-density lipoprotein receptor-related protein-1 and hemopexin were increased in ipsilateral brain after intracerebral hemorrhage, accompanied by increased hemoglobin levels, brain water content, blood-brain barrier permeability and neurological deficits. Exogenous human recombinant low-density lipoprotein receptor-related protein-1 protein reduced hematoma volume, brain water content surrounding hematoma, blood-brain barrier permeability and improved neurological function three days after intracerebral hemorrhage. The expression of malondialdehyde, fluoro-Jade C positive cells and cleaved caspase 3 was increased three days after intracerebral hemorrhage in the ipsilateral brain tissues and decreased with recombinant low-density lipoprotein receptor-related protein-1. Intracerebral hemorrhage decreased and recombinant low-density lipoprotein receptor-related protein-1 increased the levels of superoxide dismutase 1. Low-density lipoprotein receptor-related protein-1 siRNA reduced the effect of human recombinant low-density lipoprotein receptor-related protein-1 on all outcomes measured. Collectively, our findings suggest that low-density lipoprotein receptor-related protein-1 contributed to heme clearance and blood-brain barrier protection after intracerebral hemorrhage. The use of low-density lipoprotein receptor-related protein-1 as supplement provides a novel approach to ameliorating intracerebral hemorrhage brain injury via its pleiotropic neuroprotective effects.

Indexed as

AnimalsBehavior, AnimalBlood-Brain BarrierCapillary PermeabilityCerebral HemorrhageHemeHemopexinLow Density Lipoprotein Receptor-Related Protein-1MaleMice, Inbred StrainsNeuroprotective AgentsReceptors, LDLRecombinant ProteinsTumor Suppressor ProteinsHemeHemopexinLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseNeuroprotective AgentsReceptors, LDLRecombinant ProteinsTumor Suppressor Proteinsblood–brain barrier permeabilitybrain edemaheme scavengingIntracerebral hemorrhagelow-density lipoprotein receptor-related protein-1

Identifiers

PMID27317656
PMCPMC5453452
OpenAlexW2436837830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.