Evidence map›Paper›PMID 27317630›Full record

ArticleJMIR research protocols2016

Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia? - Protocol for a 3-Tesla MRI Study of Healthy Volunteers.

Morten Sejer Hansen, Mohammad Sohail Asghar, Jørn Wetterslev, Christian Bressen Pipper, Johan Johan Mårtensson, Lino Becerra, Anders Christensen, Janus Damm Nybing, Inger Havsteen, Mikael Boesen and 1 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02527395 nacompletednot on this map

To Determine the Degree of Association Between Heat Pain Detection Threshold and Area of Secondary Hyperalgesia Following Brief Thermal Sensitization in Healthy Male Volunteers

TypeinterventionalSponsorRigshospitalet, DenmarkRan2015 to 2015Enrolled121ConditionsHealthyArmsBrief thermal sensitization, Pain during 1 min. thermal stimulation, Heat pain detection threshold
NCT02567318 nacompletednot on this map

Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia? - A Study of Healthy Volunteers

TypeinterventionalSponsorRigshospitalet, DenmarkRan2015 to 2015Enrolled120ConditionsPain, Secondary Hyperalgesia, Healthy Volunteers, Magnetic Resonance ImagingArmsMRI-scan
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Morten Sejer HansenDepartment of Anaesthesiology, 4231, Centre of head and orthopaedics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. morten.sejer.hansen@regionh.dk.ORCID http://orcid.org/0000-0002-1568-3831
Mohammad Sohail AsgharORCID http://orcid.org/0000-0002-3759-2674
Jørn WetterslevORCID http://orcid.org/0000-0001-7778-1771
Christian Bressen PipperORCID http://orcid.org/0000-0003-0261-616X
Johan Johan MårtenssonORCID http://orcid.org/0000-0003-1620-7527
Lino BecerraORCID http://orcid.org/0000-0002-5840-1160
Anders ChristensenORCID http://orcid.org/0000-0003-1325-9049
Janus Damm NybingORCID http://orcid.org/0000-0003-3066-3908
Inger HavsteenORCID http://orcid.org/0000-0002-8110-8931
Mikael BoesenORCID http://orcid.org/0000-0002-8774-6563
Jørgen Berg DahlORCID http://orcid.org/0000-0002-5913-456X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExperience and development of pain may be influenced by a number of physiological, psychological, and psychosocial factors. In a previous study we found differences in neuronal activation to noxious stimulation, and microstructural neuroanatomical differences, when comparing healthy volunteers with differences in size of the area of secondary hyperalgesia following a standardized burn injury.

objectiveWe aim to investigate the degree of association between the volume of pain-relevant structures in the brain and the size of the area of secondary hyperalgesia following brief thermal sensitization.

methodsThe study consists of one experimental day, in which whole-brain magnetic resonance imaging (MRI) scans will be conducted including T1-weighed three-dimensional anatomy scan, diffusion tensor imaging, and resting state functional MRI. Before the experimental day, all included participants will undergo experimental pain testing in a parallel study (Clinicaltrials.gov Identifier: NCT02527395). Results from this experimental pain testing, as well as the size of the area of secondary hyperalgesia from the included participants, will be extracted from this parallel study.

resultsThe association between the volume of pain-relevant structures in the brain and the area of secondary hyperalgesia will be investigated by linear regression of the estimated best linear unbiased predictors on the individual volumes of the pain relevant brain structures.

conclusionsWe plan to investigate the association between experimental pain testing parameters and the volume, connectivity, and resting state activity of pain-relevant structures in the brain. These results may improve our knowledge of the mechanisms responsible for the development of acute and chronic pain. CLINICALTRIAL: Danish Research Ethics Committee (identifier: H-15010473). Danish Data Protection Agency (identifier: RH-2015-149). Clinicaltrials.gov NCT02567318; http://clinicaltrials.gov/ct2/show/NCT02567318 (Archived by WebCite at http://www.webcitation.org/6i4OtP0Oi).

Indexed as

AnaesthesiologyCentral sensitizationHyperalgesiaMagnetic resonance imagingPainPhysiologyQuantitative sensory testing

Identifiers

PMID27317630
PMCPMC4930528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.