ArticleJournal of clinical hypertension (Greenwich, Conn.)2016
The Relationship Between Left Ventricular Wall Thickness, Myocardial Shortening, and Ejection Fraction in Hypertensive Heart Disease: Insights From Cardiac Magnetic Resonance Imaging.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Reappraising cardiac function with myocardial contraction fraction: normal values, disease detection, and prognostication.European heart journal. Cardiovascular Imaging · 2026Article
- Evaluation of Preoperative Left Ventricular Relative Wall Thickness for Predicting Postoperative Acute Kidney Injury in Elderly Hip Fracture Patients.Journal of clinical medicine · 2026Article
- Peak myocardial work index: a novel nonproprietary approach for the assessment of global constructive myocardial work by strain echocardiography.The international journal of cardiovascular imaging · 2025Article
- Myocardial active strain energy density and contractance: novel prognostic tools for left ventricular function and cardiovascular risk.European heart journal. Imaging methods and practice · 2025Review
- Global longitudinal active strain energy density (GLASED): a powerful prognostic marker in a community-based cohort.European heart journal. Cardiovascular Imaging · 2024Article
- Global longitudinal active strain energy density (GLASED): age and sex differences between young and veteran athletes.Echo research and practice · 2024Article
- Left ventricular ejection fraction: clinical, pathophysiological, and technical limitations.Frontiers in cardiovascular medicine · 2024Review
- Association between epicardial adipose tissue and myocardial work by non-invasive left ventricular pressure-strain loop in people with suspected metabolic syndrome.Scientific reports · 2023Article
- Prognostic implications of left ventricular inward displacement assessed by cardiac magnetic resonance imaging in patients with myocardial infarction.The international journal of cardiovascular imaging · 2023Article
- Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome.Journal of cardiovascular translational research · 2023Article
- Left ventricular active strain energy density is a promising new measure of systolic function.Scientific reports · 2022Article
- Implementation and prospective clinical validation of AI-based planning and shimming techniques in cardiac MRI.Medical physics · 2022Article
- The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease.Frontiers in cardiovascular medicine · 2022Article
- Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Left ventricular ejection fraction: how to improve an established index?The international journal of cardiovascular imaging · 2021Article
- The corrected left ventricular ejection fraction: a potential new measure of ventricular function.The international journal of cardiovascular imaging · 2021Article
- Linking statistical shape models and simulated function in the healthy adult human heart.PLoS computational biology · 2021Article
- Effect of pericardial incision on left ventricular morphology and systolic function in patients during coronary artery bypass grafting.Cardiovascular ultrasound · 2020Article
- Association of Hypertensive Intracerebral Hemorrhage with Left Ventricular Hypertrophy on Transthoracic Echocardiography.Journal of clinical medicine · 2020Article
- Sensitive marker for evaluation of hypertensive heart disease: extracellular volume and myocardial strain.BMC cardiovascular disorders · 2020Article
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Authors and funding
14 authors at 4 institutions in 1 country.
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Abstract
Hypertensive heart disease is often associated with a preserved left ventricular ejection fraction despite impaired myocardial shortening. The authors investigated this paradox in 55 hypertensive patients (52±13 years, 58% male) and 32 age- and sex-matched normotensive control patients (49±11 years, 56% male) who underwent cardiac magnetic resonance imaging at 1.5T. Long-axis shortening (R=0.62), midwall fractional shortening (R=0.68), and radial strain (R=0.48) all decreased (P<.001) as end-diastolic wall thickness increased. However, absolute wall thickening (defined as end-systolic minus end-diastolic wall thickness) was maintained, despite the reduced myocardial shortening. Absolute wall thickening correlated with ejection fraction (R=0.70, P<.0001). In multiple linear regression analysis, increasing wall thickness by 1 mm independently increased ejection fraction by 3.43 percentage points (adjusted β-coefficient: 3.43 [2.60-4.26], P<.0001). Increasing end-diastolic wall thickness augments ejection fraction through preservation of absolute wall thickening. Left ventricular ejection fraction should not be used in patients with hypertensive heart disease without correction for degree of hypertrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.