ArticleBMC developmental biology2016
MR microscopy of the human fetal upper extremity - a proof-of-principle study.
Article in BMC developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Novel imaging techniques to study postmortem human fetal anatomy: a systematic review on microfocus-CT and ultra-high-field MRI.European radiology · 2020Pooled it
- Altricial Patterns in Prenatal Skeletal Development of Two Large Neotropical Primates: The Poeppig's Woolly Monkey and the Juruá Red Howler Monkey.American journal of primatology · 2026Article
- Imaging of Embryonic and Fetal Brain Development Using MRI Microscopy: Achieving High Spatial Resolution.Medical sciences (Basel, Switzerland) · 2026Review
- Ultra-high-field MRI of postmortem human fetal wrist joints: initial experience.European radiology experimental · 2023Article
- Comparison of postmortem whole-body contrast-enhanced microfocus computed tomography and high-field magnetic resonance imaging of human fetuses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
- A new biometric: In utero growth curves for metacarpal and phalangeal lengths reveal an embryonic patterning ratio.Prenatal diagnosis · 2019Article
- Ultrahigh-Field Quantitative MR Microscopy of the Chicken Eye In Vivo Throughout the In Ovo Period.Molecular imaging and biology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an example, this study explores the potential of magnetic resonance microscopy (MRM) for the assessment of the development of the fetal upper extremity and discusses its correlation with histological findings.
methodsEx vivo MRM at 7.1 T (Clin Scan, Bruker Biospin, Germany) was performed in 10 human specimens at 8 to 12 weeks of gestational age (GA). In-plane resolution was 20 μm with a slice thickness of 70 μm. MRM was followed by histological work-up of the specimens. MRM images were then correlated with conventional histology with a focus on the presence of chondrification and ossification.
resultsOssification of the upper human extremity is detectable at 8 weeks GA in the humerus and the long bones of the forearm. There is excellent correlation for location and size of ossification between MRM and conventional histology. MRM imaging is in accordance with historical studies.
conclusionEx vivo MRM for the non-invasive assessment of the embryonic and fetal development of the upper human extremity is feasible. It may provide an accurate complementary tool for the evaluation of embryological development.
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