ArticleJournal of neuroscience research2016
Associations between brain white matter integrity and disease severity in obstructive sleep apnea.
Article in Journal of neuroscience research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The micro-structural changes in white matter fibers associated with anxiety and depression in moderate-severe obstructive sleep apnea.Scientific reports · 2026Article
- Changes in the Spatial Structure of Synchronization Connections in EEG During Nocturnal Sleep Apnea.Clocks & sleep · 2024Article
- Volumetric analysis of the hypothalamic subunits in obstructive sleep apnea.Brain and behavior · 2024Article
- Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Machine learning approach for obstructive sleep apnea screening using brain diffusion tensor imaging.Journal of sleep research · 2023Article
- Relationships between brain tissue damage, oxygen desaturation, and disease severity in obstructive sleep apnea evaluated by diffusion tensor imaging.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Brain tissue integrity mapping in adults with obstructive sleep apnea using T1-weighted and T2-weighted images.Therapeutic advances in neurological disorders · 2022Article
- Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice.Neuroscience bulletin · 2021Article
- Associations between sleep apnea and advanced brain aging in a large-scale population study.Sleep · 2021Article
- Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease.PloS one · 2021Article
- The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome.Journal of neuroinflammation · 2020Review
- Regional brain tissue integrity in pediatric obstructive sleep apnea.Neuroscience letters · 2018Article
- Brain abnormalities in cognition, anxiety, and depression regulatory regions in adolescents with single ventricle heart disease.Journal of neuroscience research · 2018Article
- Preface for the 3rd Clinical Update Sleep, 23rd February 2018, Royal College of Physicians, London, UK: year in review.Journal of thoracic disease · 2018Article
- Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies.Current sleep medicine reports · 2017Article
- Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI.Neuropsychiatric disease and treatment · 2017Article
- Evaluation of cerebral microstructural changes in adult patients with obstructive sleep apnea by MR diffusion kurtosis imaging using a whole-brain atlas.The Indian journal of radiology & imagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway blockage, with continued diaphragmatic efforts to breathe during sleep. Brain structural changes in OSA appear in various regions, including white matter sites that mediate autonomic, mood, cognitive, and respiratory control. However, the relationships between brain white matter changes and disease severity in OSA are unclear. This study examines associations between an index of tissue integrity, magnetization transfer (MT) ratio values (which show MT between free and proton pools associated with tissue membranes and macromolecules), and disease severity (apnea-hypopnea index [AHI]) in OSA subjects. We collected whole-brain MT imaging data from 19 newly diagnosed, treatment-naïve OSA subjects (50.4 ± 8.6 years of age, 13 males, AHI 39.7 ± 24.3 events/hr], using a 3.0-Tesla MRI scanner. With these data, whole-brain MT ratio maps were calculated, normalized to common space, smoothed, and correlated with AHI scores by using partial correlation analyses (covariates, age and gender; P < 0.005). Multiple brain sites in OSA subjects, including superior and inferior frontal regions, ventral medial prefrontal cortex and nearby white matter, midfrontal white matter, insula, cingulate and cingulum bundle, internal and external capsules, caudate nuclei and putamen, basal forebrain, hypothalamus, corpus callosum, and temporal regions, showed principally lateralized negative correlations (P < 0.005). These regions showed significant correlations even with correction for multiple comparisons (cluster-level, family-wise error, P < 0.05), except for a few superior frontal areas. Predominantly negative correlations emerged between local MT values and OSA disease severity, indicating potential usefulness of MT imaging for examining the OSA condition. These findings indicate that OSA severity plays a significant role in white matter injury. © 2016 Wiley Periodicals, Inc.
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