Evidence map›Paper›PMID 27315767›Full record

ArticleThe Journal of allergy and clinical immunology2017

Dysregulation of type 2 innate lymphoid cells and T

Katrien C De Grove, Sharen Provoost, Rudi W Hendriks, Andrew N J McKenzie, Leen J M Seys, Smitha Kumar, Tania Maes, Guy G Brusselle, Guy F Joos

Open access · hybridAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies.International journal of environmental research and public health · 2019
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?Current opinion in allergy and clinical immunology · 2025
    Review
  8. Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate iBALT de Novo Formation.International journal of environmental research and public health · 2022
    Article
  16. Article
  17. Review
  18. Transfer factors peptides (Imuno TFFrontiers in immunology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Katrien C De GroveDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
Sharen ProvoostDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium. Electronic address: sharen.provoost@UGent.be.
Rudi W HendriksDepartment of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
Andrew N J McKenzieMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom.
Leen J M SeysDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
Smitha KumarDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
Tania MaesDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
Guy G BrusselleDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
Guy F JoosDepartment of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
Ghent University Hospital · BEErasmus MC · NLMRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105178805
6 · The paper itself

Abstract

backgroundAlthough the prominent role of T

objectiveWe sought to investigate the relative contribution of ILC2 and adaptive T

methodsWild-type, Gata-3

resultsConcomitant DEP+HDM exposure significantly enhanced allergic airway inflammation, as characterized by increased airway eosinophilia, goblet cell metaplasia, accumulation of ILC2s and T

conclusionThese data indicate that dysregulation of ILC2s and T

Indexed as

Air PollutantsParticulate MatterVehicle EmissionsAdaptive ImmunityAnimalsAntigens, DermatophagoidesBronchoalveolar Lavage FluidCells, CulturedCytokinesFemaleGATA3 Transcription FactorImmunity, InnateLungLymph NodesLymphocytesMice, Inbred C57BLAir PollutantsAntigens, DermatophagoidesCytokinesGata3 protein, mouseGATA3 Transcription FactorParticulate MatterVehicle EmissionsasthmaDiesel exhaust particleshouse dust miteT(H)2 responsetype 2 innate lymphoid cell

Identifiers

PMID27315767
PMCPMC5420012
OpenAlexW2385846048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.