ReviewJournal of neurology2017
Proximal nerve lesions in early Guillain-Barré syndrome: implications for pathogenesis and disease classification.
Review in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.Journal of neurology · 2021Pooled it
- Dynamics of Nerve Conduction Studies in Patients With Guillain-Barré Syndrome.Muscle & nerve · 2026Article
- MR neurography of tibial and common peroneal nerves in patients with Guillain-Barre syndrome and electrophysiological correlation.BMC neurology · 2026Article
- Unilateral facial palsy with hemiplegia and positive anti-GT1a antibody: a case report and literature review.Frontiers in immunology · 2026Review
- Ultrasonographic Evaluation of Peripheral Nerves for Early Diagnosis of Guillain-Barré Syndrome: A Case-Control Study.Health science reports · 2025Article
- Blood nerve barrier permeability enables nerve targeting of circulating nanoparticles in experimental autoimmune neuritis.Scientific reports · 2025Article
- Prognostic factors of mechanical ventilation in Guillain-Barré syndrome among adults and children in Vietnam.Clinical neurophysiology practice · 2025Article
- Electrodiagnostic subtyping in Guillain-Barré syndrome patients in the International Guillain-Barré Outcome Study.European journal of neurology · 2024Article
- Article
- Semiquantitative assessment of preganglionic nerves for chronic immune-mediated neuropathies using brachial plexus magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Nerve ultrasound in Guillain-Barré syndrome: what the recent literature says.Acta neurologica Belgica · 2024Article
- Neurologic pathologies of the vertebral spine.Skeletal radiology · 2024Review
- Predictors of respiratory failure in Guillain-Barré syndrome: a 22 year cohort study from a single Italian centre.European journal of neurology · 2024Article
- Molecular, Electrophysiological, and Ultrasonographic Differences in Selected Immune-Mediated Neuropathies with Therapeutic Implications.International journal of molecular sciences · 2023Review
- COVID-19: a modern trigger for Guillain-Barre syndrome, myasthenia gravis, and small fiber neuropathy.Frontiers in neuroscience · 2023Review
- Review
- A novel prognostic system based on clinical and laboratory parameters for childhood Guillain-Barre syndrome.Acta neurologica Belgica · 2022Article
- Physiotherapy management of a rare variant of Guillain Barre Syndrome, acute motor and sensory axonal neuropathy (AMSAN) along with COVID-19 in a 35-year-old male -a case report.African health sciences · 2022Article
- Electrodiagnostic subtyping in Guillain-Barré syndrome: Use of criteria in practice based on a survey study in IGOS.Journal of the peripheral nervous system : JPNS · 2022Article
- MRI of the intraspinal nerve roots in patients with chronic inflammatory neuropathies: abnormalities correlate with clinical phenotypes.Journal of neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guillain-Barré syndrome (GBS) is an acute-onset, immune-mediated disorder of the peripheral nervous system. In early GBS, arbitrarily established up to 10 days of disease onset, patients could exhibit selective manifestations due to involvement of the proximal nerves, including nerve roots, spinal nerves and plexuses. Such manifestations are proximal weakness, inaugural nerve trunk pain, and atypical electrophysiological patterns, which may lead to delayed diagnosis. The aim of this paper was to analyze the nosology of early GBS reviewing electrophysiological, autopsy and imaging studies, both in acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor/motor-sensory axonal neuropathy (AMAN/AMSAN). Early electrophysiology showed either well-defined demyelinating or axonal patterns, or a non-diagnostic pattern with abnormal late responses; there may be attenuated M responses upon lumbar root stimulation as the only finding. Pathological changes predominated in proximal nerves, in some studies, most prominent at the sides where the spinal roots unite to form the spinal nerves; on very early GBS endoneurial inflammatory edema was the outstanding feature. In the far majority of cases, spinal magnetic resonance imaging showed contrast enhancement of cauda equina, selectively involving anterior roots in AMAN. Both in AIDP and AMAN/AMSAN, ultrasonography has demonstrated frequent enlargement of ventral rami of C5-C7 nerves with blurred boundaries, whereas sonograms of upper and lower extremity peripheral nerves exhibited variable and less frequent abnormalities. We provide new insights into the pathogenesis and classification of early GBS.
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