ReviewDevelopmental neurobiology2017
Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.
Review in Developmental neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Rapid, interpretable data-driven models of neural dynamics using recurrent mechanistic models.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Electrical synapse molecular diversity revealed by proximity-based proteomic discovery.bioRxiv : the preprint server for biology · 2024Article
- Article
- Switching neuron contributions to second network activity.Journal of neurophysiology · 2024Article
- Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Synchronization of inspiratory burst onset along the ventral respiratory column in the neonate mouse is mediated by electrotonic coupling.BMC biology · 2023Article
- Contribution of membrane-associated oscillators to biological timing at different timescales.Frontiers in physiology · 2023Article
- Resolving inter-regional communication capacity in the human connectome.Network neuroscience (Cambridge, Mass.) · 2023Article
- Distinct mechanisms underlie electrical coupling resonance and its interaction with membrane potential resonance.Frontiers in systems biology · 2023Article
- Neural circuit regulation by identified modulatory projection neurons.Frontiers in neuroscience · 2023Review
- Multiple intrinsic membrane properties are modulated in a switch from single- to dual-network activity.Journal of neurophysiology · 2022Article
- Article
- Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.eLife · 2022Article
- Degeneracy measures in biologically plausible random Boolean networks.BMC bioinformatics · 2022Article
- The Consistency of Gastropod Identified Neurons Distinguishes Intra-Individual Plasticity From Inter-Individual Variability in Neural Circuits.Frontiers in behavioral neuroscience · 2022Review
- Feeding state-dependent modulation of feeding-related motor patterns.Journal of neurophysiology · 2021Article
- Neuronal Switching between Single- and Dual-Network Activity via Modulation of Intrinsic Membrane Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Gap junction-mediated glycinergic inhibition ensures precise temporal patterning in vocal behavior.eLife · 2021Article
- TheFrontiers in neural circuits · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Electrical coupling in circuits can produce non-intuitive circuit dynamics, as seen in both experimental work from the crustacean stomatogastric ganglion and in computational models inspired by the connectivity in this preparation. Ambiguities in interpreting the results of electrophysiological recordings can arise if sets of pre- or postsynaptic neurons are electrically coupled, or if the electrical coupling exhibits some specificity (e.g. rectifying, or voltage-dependent). Even in small circuits, electrical coupling can produce parallel pathways that can allow information to travel by monosynaptic and/or polysynaptic pathways. Consequently, similar changes in circuit dynamics can arise from entirely different underlying mechanisms. When neurons are coupled both chemically and electrically, modifying the relative strengths of the two interactions provides a mechanism for flexibility in circuit outputs. This, together with neuromodulation of gap junctions and coupled neurons is important both in developing and adult circuits. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 597-609, 2017.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.