ArticleJournal of Alzheimer's disease : JAD2016
Changes in Frailty Predict Changes in Cognition in Older Men: The Honolulu-Asia Aging Study.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Prevalence and related factors of cognitive frailty in diabetic patients in China: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Joint Trajectories of Frailty and Cognitive Function in Older Koreans Based on 14-Year Period Data From Korean Longitudinal Study of Aging (KLoSA).Geriatrics & gerontology international · 2026Article
- A nomogram as a screening tool for mild cognitive impairment in middle-aged and elderly patients with atrial fibrillation.Scientific reports · 2026Article
- The smart home, a true home? How new technologies disrupt the experience of home for older persons.Universal access in the information society · 2025Article
- Differential interplay between multimorbidity patterns and frailty and their mutual mediation effect on mortality in old age.The journal of nutrition, health & aging · 2024Article
- Factors affecting cognitive frailty improvement and progression in Taiwanese older adults.BMC geriatrics · 2024Article
- Application of a Social Vulnerability Index and Its Associations with Physical Frailty and Disability in a Cross-sectional Study of Older Kenyan Women Living with and without HIV.The Journal of frailty & aging · 2024Article
- Frailty is associated with the clinical expression of neuropsychological deficits in older adults.European journal of neurology · 2024Article
- Weight variability, physical functioning and incident disability in older adults.Journal of cachexia, sarcopenia and muscle · 2023Article
- Frailty trajectory predicts subsequent cognitive decline: A 26-year population-based longitudinal cohort study.MedComm · 2023Article
- Knowledge Gaps, Challenges, and Opportunities in Health and Prevention Research for Asian Americans, Native Hawaiians, and Pacific Islanders: A Report From the 2021 National Institutes of Health Workshop.Annals of internal medicine · 2022Article
- Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke?BMC geriatrics · 2022Article
- The role of vitamin D in the link between physical frailty and cognitive function: A mediation analysis in community-dwelling Chinese older adults.Frontiers in nutrition · 2022Article
- 10-year frailty trajectory is associated with Alzheimer's dementia after considering neuropathological burden.Aging medicine (Milton (N.S.W)) · 2021Article
- The Social Vulnerability Index, Mortality and Disability in Mexican Middle-Aged and Older Adults.Geriatrics (Basel, Switzerland) · 2021Article
- Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates.Transplantation direct · 2021Article
- Relationships Among Cognitive Function, Frailty, and Health Outcome in Community-Dwelling Older Adults.Frontiers in aging neuroscience · 2021Article
- Clinical and Neuropsychological Correlates of Prefrailty Syndrome.Frontiers in medicine · 2020Article
- CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus.Alzheimer's & dementia (New York, N. Y.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAs cognitive decline mostly occurs in late life, where typically it co-exists with many other ailments, it is important to consider frailty in understanding cognitive change.
objectiveHere, we examined the association of change in frailty status with cognitive trajectories in a well-studied cohort of older Japanese-American men.
methodsUsing the prospective Honolulu-Asia Aging Study (HAAS), 2,817 men of Japanese descent were followed (aged 71-93 at baseline). Starting in 1991 with follow-up health assessments every two to three years, cognition was measured using the Cognitive Abilities Screening Instrument (CASI). For this study, health data was used to construct an accumulation of deficits frailty index (FI). Using six waves of data, multilevel growth curve analyses were constructed to examine simultaneous changes in cognition in relation to changes in FI, controlling for baseline frailty, age, education, and APOE-ɛ4 status.
resultsOn average, CASI scores declined by 2.0 points per year (95% confidence interval 1.9-2.1). Across six waves, each 10% within-person increase in frailty from baseline was associated with a 5.0 point reduction in CASI scores (95% confidence interval 4.7-5.2). Baseline frailty and age were associated both with lower initial CASI scores and with greater decline across the five follow-up assessments (p < 0.01). DISCUSSION: Cognition is adversely affected by impaired health status in old age. Using a multidimensional measure of frailty, both baseline status and within-person changes in frailty were predictive of cognitive trajectories.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.