Evidence map›Paper›PMID 27314456›Full record

ReviewClinical and experimental immunology2017

Ageing and obesity similarly impair antibody responses.

D Frasca, A Diaz, M Romero, B B Blomberg

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

D FrascaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, USA.
A DiazDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, USA.
M RomeroDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, USA.
B B BlombergDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, USA.
University of Miami · US

Funding

Regulation of Immunoglobulin Class Switch in Aged MiceR37AG023717 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B. · 2005 to 2014
$3.3M
Regulation of B Lymphocyte Defects in Senescent HumansR01AG032576 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B. · 2009 to 2014
$1.6M
Regulation of primary and memory B cell vaccine responses in the elderlyR56AG032576 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B., FRASCA, DANIELA · 2015 to 2015
$598k
Micro-RNAs: a new mechanism negatively regulating B cell responses in the elderlyR21AG042826 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B., FRASCA, DANIELA · 2013 to 2014
$422k
Molecular mechanisms for TNF-mediated inhibition of B lymphocyte functionR21AI096446 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B., FRASCA, DANIELA · 2012 to 2013
$407k
NIAID NIH HHS R21 AI096446NIA NIH HHS R01 AG032576NIA NIH HHS R21 AG042826NIA NIH HHS R37 AG023717NIA NIH HHS R56 AG032576
6 · The paper itself

Abstract

Ageing is characterized by increased low-grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low-grade chronic inflammation in ageing and obesity and on the mechanisms involved.

Indexed as

Antibody FormationImmunosenescenceAdaptive ImmunityAgedAgingAnimalsB-LymphocytesHumansImmunity, InnateInflammationObesityRiskagingB cellsinflammationobesity

Identifiers

PMID27314456
PMCPMC5167022
OpenAlexW2437879083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.