Evidence map›Paper›PMID 27314418›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2016

Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure.

Shiro Ishihara, Etienne Gayat, Naoki Sato, Mattia Arrigo, Said Laribi, Matthieu Legrand, Rui Placido, Philippe Manivet, Alain Cohen-Solal, William T Abraham and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  3. Noninvasive pulse contour analysis for determination of cardiac output in patients with chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018
    Trial
  4. Trial
  5. An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Perioperative approach to precapillary pulmonary hypertension in non-cardiac non-obstetric surgery.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Management of Acute Heart Failure during an Early Phase.International journal of heart failure · 2020
    Review
  16. Acute heart failure.Nature reviews. Disease primers · 2020 · on this map
    Review
  17. Review
  18. Review
  19. Prognostic value of estimated plasma volume in acute heart failure in three cohort studies.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 5 countries.

Shiro IshiharaCardiology Department, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
Etienne GayatInserm UMR-S 942, Paris, France.
Naoki SatoCardiology Department, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
Mattia ArrigoInserm UMR-S 942, Paris, France.ORCID http://orcid.org/0000-0003-4028-2869
Said LaribiInserm UMR-S 942, Paris, France.
Matthieu LegrandInserm UMR-S 942, Paris, France.
Rui PlacidoInserm UMR-S 942, Paris, France.
Philippe ManivetInserm UMR-S 942, Paris, France.
Alain Cohen-SolalInserm UMR-S 942, Paris, France.
William T AbrahamDivision of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
Mariell JessupThe Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Alexandre MebazaaInserm UMR-S 942, Paris, France. alexandre.mebazaa@aphp.fr.
Inserm · FRNippon Steel Yawata Memorial Hospital · JPThe Ohio State University · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute heart failure (AHF) with reduced left-ventricular ejection fraction (LVEF) is often a biventricular congested state. The comparative effect of vasodilators and inotropes on the right- and/or left-sided congestion is unknown. METHODS AND

resultsA systematic review, meta-analysis, and meta-regression of AHF studies using pulmonary artery catheter were performed using PubMed, Embase, and Cochrane library. Data from 35 studies, including 3016 patients, were studied. Included patients had a weighted mean age of 60 years, left-ventricular ejection fraction (LVEF) of 24 %, and plasma B-type natriuretic peptide (BNP) of 892 pg/ml. Both the left- and right-ventricular filling pressures were elevated: weighted mean pulmonary artery wedge pressure (PAWP) was 25 mmHg (range 17-31 mmHg) and right atrial pressure (RAP) 12 mmHg (range 7-18 mmHg). Vasodilators and inotropes had similar beneficial effects on PAWP [-6.3 mmHg (95 % CI -7.4 to -5.2 mmHg) and -5.8 mmHg (95 % CI -7.6 to -4.0 mmHg), respectively] and RAP [-2.9 mmHg (95 % CI -3.8 to -2.1 mmHg) and -2.8 mmHg (95 % CI -3.8 to -1.7 mmHg), respectively]. Among inotropes, inodilators, such as levosimendan, have greater beneficial effect on the left-ventricular filling pressure than dobutamine. Drug-induced improvement of PAWP tightly paralleled that of RAP with all studied drugs (r

conclusionThe left- and right-sided filling pressures are similarly improved by vasodilators or inotropes, in AHF with reduced LVEF.

Indexed as

Cardiotonic AgentsHeart FailureHumansMyocardial ContractionRecovery of FunctionStroke VolumeTreatment OutcomeVasodilationVasodilator AgentsVentricular Dysfunction, LeftVentricular Dysfunction, RightVentricular Function, LeftVentricular Function, RightVentricular PressureCardiotonic AgentsVasodilator AgentsAcute heart failureCongestionDecongestionHemodynamicsInotropesMeta-analysisMeta-regressionVasodilators

Identifiers

PMID27314418
OpenAlexW2431053157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.