ArticleViruses2016
Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts.
Article in Viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 49 citations in OpenAlex.
- Ferrets and genetically modified ferrets as model organisms in biomedical research: a review.Frontiers in genome editing · 2026Review
- Current Advances and Applications of Animal Models in SARS-CoV-2 Pathogenesis and Vaccine Development.Microorganisms · 2025Review
- Syrian hamsters (Mesocricetus auratus) as an upper respiratory tract model for respiratory syncytial virus infection.Npj viruses · 2025Article
- Viral load in hospitalized infants with respiratory syncytial virus bronchiolitis: a three-way comparative analysis.European journal of pediatrics · 2024Article
- Ferrets as Models for Viral Respiratory Disease.Comparative medicine · 2023Review
- Ferrets: A powerful model of SARS-CoV-2.Zoological research · 2023Review
- The immune system of the ferret (Veterinarni medicina · 2022Review
- UsingExpert opinion on drug discovery · 2022Article
- The Interplay of Obesity, Dyslipidemia and Immune Dysfunction: A Brief Overview on Pathophysiology, Animal Models, and Nutritional Modulation.Frontiers in nutrition · 2022Review
- Review
- Article
- Non-human primate models of human respiratory infections.Molecular immunology · 2021Review
- Experimental Animal Models of Coronavirus Infections: Strengths and Limitations.Immune network · 2021Review
- Article
- Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells.Scientific reports · 2021Article
- Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.Nature communications · 2021Article
- The Ferret as a Model System for Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics.Cell host & microbe · 2020Review
- Human animal interface of SARS-CoV-2 (COVID-19) transmission: a critical appraisal of scientific evidence.Veterinary research communications · 2020Review
- COVID-19 pandemic: current knowledge about the role of pets and other animals in disease transmission.Virology journal · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human respiratory syncytial virus (HRSV) is an important cause of severe respiratory tract disease in immunocompromised patients. Animal models are indispensable for evaluating novel intervention strategies in this complex patient population. To complement existing models in rodents and non-human primates, we have evaluated the potential benefits of an HRSV infection model in ferrets (Mustela putorius furo). Nine- to 12-month-old HRSV-seronegative immunocompetent or immunocompromised ferrets were infected with a low-passage wild-type strain of HRSV subgroup A (10⁵ TCID50) administered by intra-tracheal or intra-nasal inoculation. Immune suppression was achieved by bi-daily oral administration of tacrolimus, mycophenolate mofetil, and prednisolone. Throat and nose swabs were collected daily and animals were euthanized four, seven, or 21 days post-infection (DPI). Virus loads were determined by quantitative virus culture and qPCR. We observed efficient HRSV replication in both the upper and lower respiratory tract. In immunocompromised ferrets, virus loads reached higher levels and showed delayed clearance as compared to those in immunocompetent animals. Histopathological evaluation of animals euthanized 4 DPI demonstrated that the virus replicated in the respiratory epithelial cells of the trachea, bronchi, and bronchioles. These animal models can contribute to an assessment of the efficacy and safety of novel HRSV intervention strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.