Evidence map›Paper›PMID 27314331›Full record

Trial reportInternational journal of molecular sciences2016

Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial.

Cristina Buigues, Julio Fernández-Garrido, Leo Pruimboom, Aldert J Hoogland, Rut Navarro-Martínez, Mary Martínez-Martínez, Yolanda Verdejo, Mari Carmen Mascarós, Carlos Peris, Omar Cauli

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 13 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 13 syntheses or guidelines pooled it, 212 citations in OpenAlex.

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  10. Understanding the gut microbiota and sarcopenia: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021
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  19. Eight Weeks ofNutrients · 2023
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Cristina BuiguesDepartment of Nursing, University of Valencia, Valencia 46010, Spain. cristina.buigues@uv.es.
Julio Fernández-GarridoDepartment of Nursing, University of Valencia, Valencia 46010, Spain. julio.fernandez@uv.es.
Leo PruimboomNatura Foundation, Numansdorp 3281 NC, The Netherlands. cpni.pruimboom@icloud.com.
Aldert J HooglandBonusan Besloten Vennootschap, Numansdorp 3280 AA, The Netherlands. a.hoogland@bonusan.nl.
Rut Navarro-MartínezDepartment of Nursing, University of Valencia, Valencia 46010, Spain. rut.navarro@uv.es.
Mary Martínez-MartínezGeroResidencias La Saleta, Valencia 46015, Spain. mmartinez@lasaleta.com.
Yolanda VerdejoGeroResidencias La Saleta, Valencia 46015, Spain. supelpuig@saleta.com.
Mari Carmen MascarósGeroResidencias La Saleta, Valencia 46015, Spain. supcampolivar@saleta.com.
Carlos PerisGeroResidencias La Saleta, Valencia 46015, Spain. betera@lasaleta.com.
Omar CauliDepartment of Nursing, University of Valencia, Valencia 46010, Spain. omar.cauli@uv.es.
Universitat de València · ESUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging can result in major changes in the composition and metabolic activities of bacterial populations in the gastrointestinal system and result in impaired function of the immune system. We assessed the efficacy of prebiotic Darmocare Pre(®) (Bonusan Besloten Vennootschap (BV), Numansdorp, The Netherlands) to evaluate whether the regular intake of this product can improve frailty criteria, functional status and response of the immune system in elderly people affected by the frailty syndrome. The study was a placebo-controlled, randomized, double blind design in sixty older participants aged 65 and over. The prebiotic product was composed of a mixture of inulin plus fructooligosaccharides and was compared with placebo (maltodextrin). Participants were randomized to a parallel group intervention of 13 weeks' duration with a daily intake of Darmocare Pre(®) or placebo. Either prebiotic or placebo were administered after breakfast (between 9-10 a.m.) dissolved in a glass of water carefully stirred just before drinking. The primary outcome was to study the effect on frailty syndrome. The secondary outcomes were effect on functional and cognitive behavior and sleep quality. Moreover, we evaluated whether prebiotic administration alters blood parameters (haemogram and biochemical analysis). The overall rate of frailty was not significantly modified by Darmocare Pre(®) administration. Nevertheless, prebiotic administration compared with placebo significantly improved two frailty criteria, e.g., exhaustion and handgrip strength (p < 0.01 and p < 0.05, respectively). No significant effects were observed in functional and cognitive behavior or sleep quality. The use of novel therapeutic approaches influencing the gut microbiota-muscle-brain axis could be considered for treatment of the frailty syndrome.

Indexed as

Geriatric AssessmentAgedAged, 80 and overCognitionDouble-Blind MethodFatigueFemaleFrail ElderlyHand StrengthHumansInulinMalePrebioticsSarcopeniaSleepInulinPrebioticsagingbiomarkerfatigueinflammationleucocytes

Identifiers

PMID27314331
PMCPMC4926465
OpenAlexW2444248993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.