ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2016
The Solanum demissum R8 late blight resistance gene is an Sw-5 homologue that has been deployed worldwide in late blight resistant varieties.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 102 citations in OpenAlex.
- A built-in brake for plant immunity: Resistance (R) protein-mediated immunity is fine-tuned byScience advances · 2026Article
- Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026Review
- Potato StRWA2 recruits the E3 ligase StSNIPER2 to destabilize NLRs and promoteHorticulture research · 2026Article
- Late blight resistance of Julius Kühn Institute pre-breeding potato clones: a genome-wide association study.BMC plant biology · 2026Article
- Whole-genome sequencing revealed the genomic origin of Solanum demissum Lindl., a Mexican hexaploid wild potato species.BMC plant biology · 2026Article
- Phytophthora infestans RxLR Effector PiAvr3b Targets NADP-Malic Enzyme to Promote Infection.Molecular plant pathology · 2025Article
- Late blight field resistance in potatoes carryingGM crops & food · 2025Article
- Deciphering the Molecular Interplay Between RXLR-EncodedInternational journal of molecular sciences · 2025Review
- Host-induced gene silencing of the amino acid biosynthesis gene acetolactate synthase of Phytophthora infestans caused strong enhanced late blight resistance of potato in the field.Plant biotechnology journal · 2025Article
- Expression of a modified Avr3a gene under the control of a synthetic pathogen-inducible promoter leads to Phytophthora infestans resistance in potato.Plant biotechnology journal · 2025Article
- Mutations in the signal peptide of effector gene Pi04314 contribute to the adaptive evolution of the Phytophthora infestans.BMC ecology and evolution · 2025Article
- Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants.Nature communications · 2024Article
- A viral effector blocks the turnover of a plant NLR receptor to trigger a robust immune response.The EMBO journal · 2024Article
- Evolution of Phytophthora infestans on its potato host since the Irish potato famine.Nature communications · 2024Article
- Modern Breeding Strategies and Tools for Durable Late Blight Resistance in Potato.Plants (Basel, Switzerland) · 2024Review
- Review
- Establishment of an Efficient Sugarcane Transformation System via Herbicide-Resistant CP4-EPSPS Gene Selection.Plants (Basel, Switzerland) · 2024Article
- Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors.Nature genetics · 2023Article
- Nucleotide-binding leucine-rich repeat network underlies nonhost resistance of pepper against the Irish potato famine pathogen Phytophthora infestans.Plant biotechnology journal · 2023Article
- HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes.BMC bioinformatics · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
key messageThe potato late blight resistance gene R8 has been cloned. R8 is found in five late blight resistant varieties deployed in three different continents. R8 recognises Avr8 and is homologous to the NB-LRR protein Sw-5 from tomato. The broad spectrum late blight resistance gene R8 from Solanum demissum was cloned based on a previously published coarse map position on the lower arm of chromosome IX. Fine mapping in a recombinant population and bacterial artificial chromosome (BAC) library screening resulted in a BAC contig spanning 170 kb of the R8 haplotype. Sequencing revealed a cluster of at least ten R gene analogues (RGAs). The seven RGAs in the genetic window were subcloned for complementation analysis. Only one RGA provided late blight resistance and caused recognition of Avr8. From these results, it was concluded that the newly cloned resistance gene was indeed R8. R8 encodes a typical intracellular immune receptor with an N-terminal coiled coil, a central nucleotide binding site and 13 C-terminal leucine rich repeats. Phylogenetic analysis of a set of representative Solanaceae R proteins shows that R8 resides in a clearly distinct clade together with the Sw-5 tospovirus R protein from tomato. It was found that the R8 gene is present in late blight resistant potato varieties from Europe (Sarpo Mira), USA (Jacqueline Lee, Missaukee) and China (PB-06, S-60). Indeed, when tested under field conditions, R8 transgenic potato plants showed broad spectrum resistance to the current late blight population in the Netherlands, similar to Sarpo Mira.
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