SynthesisAIDS (London, England)2016
Pre-exposure prophylaxis for HIV infection and new sexually transmitted infections among men who have sex with men.
Synthesis in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 5 syntheses or guidelines pooled it, 192 citations in OpenAlex.
- Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Pooled it
- Missed opportunities for sexually transmitted infections testing for HIV pre-exposure prophylaxis users: a systematic review.Journal of the International AIDS Society · 2021Pooled it
- Global Epidemiologic Characteristics of Sexually Transmitted Infections Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Pooled it
- Awareness and willingness to use HIV pre-exposure prophylaxis among men who have sex with men in low- and middle-income countries: a systematic review and meta-analysis.Journal of the International AIDS Society · 2017Pooled it
- Effect of rectal douching/enema on rectal gonorrhoea and chlamydia among a cohort of men who have sex with men on HIV pre-exposure prophylaxis.Sexually transmitted infections · 2018Trial
- High HIV risk and syndemic burden regardless of referral source among MSM screening for a PrEP demonstration project in Toronto, Canada.BMC public health · 2018Trial
- A multicentre double-blind randomised controlled trial evaluating the efficacy of daily use of antibacterial mouthwash against oropharyngeal gonorrhoea among men who have sex with men: the OMEGA (Oral Mouthwash use to Eradicate GonorrhoeA) study protocol.BMC infectious diseases · 2017Trial
- Enhanced screening and bacterial sexually-transmitted infection diagnoses after HIV pre-exposure prophylaxis initiation.Epidemiology (Cambridge, Mass.) · 2026Article
- High Burden of Sexually Transmitted Infections Among Pre-exposure Prophylaxis (PrEP) Users: Testing and Prevention Needs.AIDS and behavior · 2026Article
- Declining prevalence of AIDS-defining illness among newly diagnosed people living with HIV in northern Thailand: a 10-year review.BMC infectious diseases · 2026Article
- Preexposure prophylaxis initiation and alcohol-related sexual risk among young men who have sex with men.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Retrospective analysis of sexually transmitted infections among people living with HIV and pre-exposure prophylaxis users in Spain.BMC infectious diseases · 2025Article
- Testing paradox may explain increased observed prevalence of bacterial STIs among MSM on HIV PrEP: A modeling study.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Routine testing for chlamydia and gonorrhea in an HIV preexposure prophylaxis program in Hanoi, Vietnam: implications for low- and middle-income countries.AIDS (London, England) · 2025Observational
- Risk Compensation in the Context of Sexually Transmitted Infections in Women Using the Dapivirine Vaginal Ring in Africa: A Scoping Review.International journal of sexual health : official journal of the World Association for Sexual Health · 2025Article
- Updates on HIV Pre-exposure Prophylaxis in Latin America: Available Drugs and Implementation Status.Le infezioni in medicina · 2025Review
- HIV Pre-Exposure Prophylaxis Cascade Stages Among Men Who Have Sex With Men With Sexually Transmitted Infections in China: Multicenter Cross-Sectional Survey Study.JMIR public health and surveillance · 2024Article
- Pre-Exposure Prophylaxis for HIV: Bioethical, Clinical, and Epidemiological Considerations.The Linacre quarterly · 2024Article
- Behind Prep Decisions: Understanding User Patterns and Discontinuation Factors in Real-World.AIDS and behavior · 2024Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We conducted a meta-analysis to summarize rates of sexually transmitted infections among men who have sex with men (MSM) on pre-exposure prophylaxis (PrEP) for HIV versus MSM not using PrEP. Incidence rate ratios showed that MSM using PrEP were 25.3 times more likely to acquire a Neisseria gonorrhoeae infection, 11.2 times more likely to acquire a Chlamydia trachomatis infection, and 44.6 times more likely to acquire a syphilis infection versus MSM not using PrEP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.