ArticleJournal of immunology research2016
Diagnostic Utility of Total IgE in Foods, Inhalant, and Multiple Allergies in Saudi Arabia.
Article in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Evaluation of the predictive value of total IgE and absolute eosinophil levels on allergy test positivity.Northern clinics of Istanbul · 2023Article
- [Diagnostic value of total serum IgE for atopy in children and adolescents].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Total serum IgE levels as predictor of the acquisition of tolerance in children with food allergy: Findings from a pilot study.Frontiers in pediatrics · 2022Article
- Intestinal proline is a potential anti-allergy factor for allergy diagnosis and therapy.Frontiers in nutrition · 2022Article
- Total and Specific Immunoglobulin E for Detection of Most Prevalent Aeroallergens in a Jordanian Cohort.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019Article
- Immunological Factors Associated with Adult Asthma in the Aseer Region, Southwestern Saudi Arabia.International journal of environmental research and public health · 2019Article
- Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action.Frontiers in pharmacology · 2019Review
- Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren.Journal of Korean medical science · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective. To assess the diagnostic significance of total IgE in foods, inhalant, and multiple allergies. Methods. Retrospective review of the laboratory records of patients who presented with clinical suspicion of food or inhalant allergy between January 2013 and December 2014. Total IgE level was defined as positive for a value >195 kU/L; and diagnosis was confirmed by the detection of specific IgE (golden standard) for at least one food or inhalant allergen and at least two allergens in multiple allergies. Results. A total of 1893 (male ratio = 0.68, mean age = 39.0 ± 19.2 years) patients were included. Total IgE had comparable sensitivity (55.8% versus 59.6%) and specificity (83.9% versus 84.4%) in food versus inhalant allergy, respectively, but a superior PPV in inhalant allergy (79.1% versus 54.4%). ROC curve analysis showed a better diagnostic value in inhalant allergies (AUC = 0.817 (95% CI = 0.796-0.837) versus 0.770 (95% CI = 0.707-0.833)). In multiple allergies, total IgE had a relatively good sensitivity (78.6%), while negative IgE testing (<195 kU/L) predicted the absence of multiple allergies with 91.5% certitude. Conclusion. Total IgE assay is not efficient as a diagnostic test for foods, inhalant, or multiple allergies. The best strategy should refer to specific IgE testing guided by a comprehensive atopic history.
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