ArticleBioMed research international2016
Biological Activities of Aerial Parts Extracts of Euphorbia characias.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- In Vitro Antioxidant, Antibacterial, and Cholinesterase-Inhibitory Properties of an Aqueous Euphorbia macroclada Root Extract Obtained by Ultrasound-Assisted Extraction.Chemistry & biodiversity · 2026Article
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- Anticholinesterase Activity of Selected Medicinal Plants from Navarra Region of Spain and a Detailed Phytochemical Investigation ofMolecules (Basel, Switzerland) · 2022Article
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- Investigation ofLife (Basel, Switzerland) · 2022Article
- Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach.Saudi journal of biological sciences · 2021Article
- Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols fromMolecules (Basel, Switzerland) · 2021Article
- Review
- Bioactive Compounds fromPharmaceuticals (Basel, Switzerland) · 2021Article
- Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Cytotoxic, Antioxidant, and Metabolic Enzyme Inhibitory Activities ofOxidative medicine and cellular longevity · 2020Article
- Review
- Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins.Molecules (Basel, Switzerland) · 2019Article
- Identification of the Potential Biological Preservative Tetramycin A-Producing Strain and Enhancing Its Production.Frontiers in microbiology · 2019Article
- Seasonal Variation in Essential Oils Composition and the Biological and Pharmaceutical Protective Effects ofBioMed research international · 2018Article
- Selected Enzyme Inhibitory Effects ofBioMed research international · 2018Article
- Broad-range potential of Asphodelus microcarpus leaves extract for drug development.BMC microbiology · 2017Article
- Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts.BMC complementary and alternative medicine · 2016Article
- Article
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11 authors.
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Abstract
The aim of the present study was to evaluate antioxidant, antimicrobial, anti-HIV, and cholinesterase inhibitory activities of aqueous and alcoholic extracts from leaves, stems, and flowers of Euphorbia characias. The extracts showed a high antioxidant activity and were a good source of total polyphenols and flavonoids. Ethanolic extracts from leaves and flowers displayed the highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase, showing potential properties against Alzheimer's disease. Antimicrobial assay showed that leaves and flowers extracts were active against all Gram-positive bacteria tested. The ethanolic leaves extract appeared to have the strongest antibacterial activity against Bacillus cereus with MIC value of 312.5 μg/mL followed by Listeria monocytogenes and Staphylococcus aureus that also exhibited good sensitivity with MIC values of 1250 μg/mL. Moreover, all the extracts possessed anti-HIV activity. The ethanolic flower extract was the most potent inhibitor of HIV-1 RT DNA polymerase RNA-dependent and Ribonuclease H with IC50 values of 0.26 and 0.33 μg/mL, respectively. The LC-DAD metabolic profile showed that ethanolic leaves extract contains high levels of quercetin derivatives. This study suggests that Euphorbia characias extracts represent a good source of natural bioactive compounds which could be useful for pharmaceutical application as well as in food system for the prevention of the growth of food-borne bacteria and to extend the shelf-life of processed foods.
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