ArticleSurgical neurology international2016
Therapeutic hypothermia and ischemic stroke: A literature review.
Article in Surgical neurology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Role of Hypothermia in Large Hemispheric Infarction: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- The Neuroprotective Effect of Therapeutic Hypothermia in Cognitive Impairment of an Ischemia/Reperfusion Injury Mouse Model.Medicina (Kaunas, Lithuania) · 2024Article
- Hyperacute immune responses associate with immediate neuropathology and motor dysfunction in large vessel occlusions.Annals of clinical and translational neurology · 2023Article
- Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia.Nature communications · 2022Article
- Hypothermia Alleviates Reductive Stress, a Root Cause of Ischemia Reperfusion Injury.International journal of molecular sciences · 2022Article
- Effect of Therapeutic Hypothermia on Liver Enzymes in Patients With Stroke.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2020Article
- Transport of ultrasmall gold nanoparticles (2 nm) across the blood-brain barrier in a six-cell brain spheroid model.Scientific reports · 2020Article
- Role of B cells and the aging brain in stroke recovery and treatment.GeroScience · 2020Review
- Novel approaches for the delivery of therapeutics in ischemic stroke.Drug discovery today · 2020Review
- Analysis of intra-operative variables as predictors of 30-day readmission in patients undergoing glioma surgery at a single center.Journal of neuro-oncology · 2019Article
- Ischaemic and hypoxic conditioning: potential for protection of vital organs.Experimental physiology · 2019Review
- Neuroprotective Agents in the Intensive Care Unit: -Neuroprotective Agents in ICU.Journal of pharmacopuncture · 2018Review
- Safety and Efficacy of Hypothermia (34°C) after Hemicraniectomy for Malignant MCA Infarction.Journal of Korean Neurosurgical Society · 2018Article
- [Antipyretics in intensive care patients].Der Anaesthesist · 2017Review
- Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke.Neural regeneration research · 2017Review
- Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke.Frontiers in neurology · 2017Review
- The cerebral circulation and cerebrovascular disease III: Stroke.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic stroke is the fifth leading cause of death in the US. Clinical techniques aimed at helping to reduce the morbidity associated with stroke have been studied extensively, including therapeutic hypothermia. In this study, the authors review the literature regarding the role of therapeutic hypothermia in ischemic stroke to appreciate the evolution of hypothermia technology over several decades and to critically analyze several early clinical studies to validate its use in ischemic stroke.
methodsA comprehensive literature search was performed using PubMed and Google Scholar databases. Search terms included "hypothermia and ischemic stroke" and "therapeutic hypothermia." A comprehensive search of the current clinical trials using clinicaltrials.gov was conducted using the keywords "stroke and hypothermia" to evaluate early and ongoing clinical trials utilizing hypothermia in ischemic stroke.
resultsA comprehensive review of the evolution of hypothermia in stroke and the current status of this treatment was performed. Clinical studies were critically analyzed to appreciate their strengths and pitfalls. Ongoing and future registered clinical studies were highlighted and analyzed compared to the reported results of previous trials.
conclusionAlthough hypothermia has been used for various purposes over several decades, its efficacy in the treatment of ischemic stroke is debatable. Several trials have proven its safety and feasibility; however, more robust, randomized clinical trials with large volumes of patients are needed to fully establish its utility in the clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.