Evidence map›Paper›PMID 27313674›Full record

ArticleExperimental and therapeutic medicine2016

Notoginsenoside Rb1 inhibits activation of ERK and p38 MAPK pathways induced by hypoxia and hypercapnia.

Xiaoxiao Qiu, Mengxiao Zheng, Dong Song, Linjing Huang, Lanlan Tang, Lei Ying, Wantie Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaoxiao QiuDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Mengxiao ZhengDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Dong SongDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Linjing HuangDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Lanlan TangDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Lei YingDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Wantie WangDepartment of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to investigate the effect of notoginsenoside Rb1 (Rb1) on the ERK and p38 MAPK pathways in primary cultured pulmonary arterial smooth muscle cells (PASMCs) exposed to hypoxia and hypercapnia, in order to elucidate the mechanism underlying the effect of Rb1 on hypoxia and hypercapnia-induced pulmonary vasoconstriction (HHPV). PASMCs were isolated from Sprague-Dawley rats. The cells were divided into five groups: Normal (N), hypoxia and hypercapnia (H), Rb

Indexed as

extracellular signal-regulated kinasehypoxia and hypercapnianotoginsenoside Rb1p38 mitogen-activated protein kinasepulmonary arterial smooth muscle cells

Identifiers

PMID27313674
PMCPMC4888033
OpenAlexW2317016724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.