ArticleEvidence-based complementary and alternative medicine : eCAM2016
Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury.
Article in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Acupuncture regulates mitochondrial homeostasis in traumatic brain injury: current evidence, mechanistic hypotheses, and translational challenges.Chinese medicine · 2026Review
- Integrated therapy including acupuncture in a patient with long-term survival from spinal cord metastases of ALK-positive lung adenocarcinoma: a case report.Frontiers in medicine · 2026Article
- Structural-Functional Dissociation in TBI Hemiplegia: Meridian-Sinew Therapy Promotes Motor Recovery Despite Corticospinal Tract Damage-A Case Report.Clinical case reports · 2025Article
- Acupuncture for Ischemic Stroke: A Critical Evaluation of Biological Mechanisms and Methodological Challenges.International journal of general medicine · 2025Review
- Acupuncture knowledge, attitudes, beliefs and health service needs after traumatic brain injury: a cross-sectional survey.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2024Article
- Efficacy of acupuncture on repair of glial scars in rats with traumatic brain injury.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Acupuncture promotes nerve repair through the benign regulation of mTOR-mediated neuronal autophagy in traumatic brain injury rats.CNS neuroscience & therapeutics · 2023Article
- The impact of acupuncture on neuroplasticity after ischemic stroke: a literature review and perspectives.Frontiers in cellular neuroscience · 2022Review
- Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies.Frontiers in pharmacology · 2022Review
- Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling.Frontiers in cellular neuroscience · 2022Article
- The roles, mechanism, and mobilization strategy of endogenous neural stem cells in brain injury.Frontiers in aging neuroscience · 2022Review
- Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.Neural regeneration research · 2021Review
- Lateral Cerebellar Nucleus Stimulation has Selective Effects on Glutamatergic and GABAergic Perilesional Neurogenesis After Cortical Ischemia in the Rodent Model.Neurosurgery · 2018Article
- Effect of acupuncture on the TLR2/4-NF-κB signalling pathway in a rat model of traumatic brain injury.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2018Article
- Role of Acupuncture in the Management of Severe Acquired Brain Injuries (sABIs).Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors.Cell transplantation · 2017Review
- The Effects of Different Factors on the Behavior of Neural Stem Cells.Stem cells international · 2017Review
- Acupuncture Improved Neurological Recovery after Traumatic Brain Injury by Activating BDNF/TrkB Pathway.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To investigate whether acupuncture induced the proliferation and differentiation of endogenous neural stem cells (NSCs) in a rat model of traumatic brain injury (TBI). Methods. 104 Sprague-Dawley rats were randomly divided into normal, model, and acupuncture groups. Each group was subdivided into three-day (3 d), seven-day (7 d), and fourteen-day (14 d) groups. The rat TBI model was established using Feeney's freefall epidural impact method. The rats in the acupuncture group were treated at acupoints (Baihui, Shuigou, Fengfu, Yamen, and bilateral Hegu). The normal and model groups did not receive acupuncture. The establishment of the rat TBI model and the therapeutic effect of acupuncture were assessed using neurobehavioral scoring and hematoxylin-eosin staining. The proliferation and differentiation of NSCs in TBI rats were analyzed using immunofluorescence microscopy. Results. The levels of nestin-expressing cells and bromodeoxyuridine/glial fibrillary acidic protein- (BrdU/GFAP-) and BrdU/S100 calcium-binding protein B-positive and BrdU/microtubule-associated protein 2- and BrdU/galactocerebrosidase-positive cells were more significantly increased at various time points in the acupuncture group than in the model group (P < 0.01), except for a decreased level of BrdU/GFAP-positive cells at 7 d and 14 d. Conclusion. Acupuncture induced the proliferation and differentiation of NSCs, thereby promoting neural repair in the TBI rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.